Anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally

Soumya Ghosh, David Hathorn, Jennifer Eisenhauer, Jesse Dixon, Ian D. Cooper

    Research output: Contribution to journalArticle

    Abstract

    In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes.

    Original languageEnglish
    Article number98
    JournalBrain Sciences
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2019

    Fingerprint

    Motor Cortex
    Leg
    Motor Evoked Potentials
    Gait
    Transcranial Magnetic Stimulation
    Nervous System Diseases
    Transcranial Direct Current Stimulation
    Muscles

    Cite this

    Ghosh, Soumya ; Hathorn, David ; Eisenhauer, Jennifer ; Dixon, Jesse ; Cooper, Ian D. / Anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally. In: Brain Sciences. 2019 ; Vol. 9, No. 5.
    @article{20f4caceea8d409f82c4d733d2d84a8f,
    title = "Anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally",
    abstract = "In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes.",
    author = "Soumya Ghosh and David Hathorn and Jennifer Eisenhauer and Jesse Dixon and Cooper, {Ian D.}",
    year = "2019",
    month = "5",
    day = "1",
    doi = "10.3390/brainsci9050098",
    language = "English",
    volume = "9",
    journal = "Brain Sciences",
    issn = "2076-3425",
    publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
    number = "5",

    }

    Anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally. / Ghosh, Soumya; Hathorn, David; Eisenhauer, Jennifer; Dixon, Jesse; Cooper, Ian D.

    In: Brain Sciences, Vol. 9, No. 5, 98, 01.05.2019.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally

    AU - Ghosh, Soumya

    AU - Hathorn, David

    AU - Eisenhauer, Jennifer

    AU - Dixon, Jesse

    AU - Cooper, Ian D.

    PY - 2019/5/1

    Y1 - 2019/5/1

    N2 - In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes.

    AB - In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes.

    UR - http://www.scopus.com/inward/record.url?scp=85068394062&partnerID=8YFLogxK

    U2 - 10.3390/brainsci9050098

    DO - 10.3390/brainsci9050098

    M3 - Article

    VL - 9

    JO - Brain Sciences

    JF - Brain Sciences

    SN - 2076-3425

    IS - 5

    M1 - 98

    ER -