Animal Models of Alzheimer's Disease

Morgan Newman, Doris Kretzschmar, Imran Khan, Mengqi Chen, Giuseppe Verdile, Michael Lardelli

Research output: Chapter in Book/Conference paperChapter

4 Citations (Scopus)

Abstract

Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition.

Original languageEnglish
Title of host publicationAnimal Models for the Study of Human Disease
PublisherAcademic Press
Chapter40
Pages1031-1085
Number of pages55
Edition2nd
ISBN (Electronic)9780124158948
ISBN (Print)9780128094686
DOIs
Publication statusPublished - 28 Jun 2017

Fingerprint

Alzheimer Disease
Animal Models
Budgets
Invertebrates
Transgenic Mice
Vertebrates
Health
Research
Late Onset Disorders

Cite this

Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G., & Lardelli, M. (2017). Animal Models of Alzheimer's Disease. In Animal Models for the Study of Human Disease (2nd ed., pp. 1031-1085). Academic Press. https://doi.org/10.1016/B978-0-12-809468-6.00040-1
Newman, Morgan ; Kretzschmar, Doris ; Khan, Imran ; Chen, Mengqi ; Verdile, Giuseppe ; Lardelli, Michael. / Animal Models of Alzheimer's Disease. Animal Models for the Study of Human Disease. 2nd. ed. Academic Press, 2017. pp. 1031-1085
@inbook{22198b70928842b180e8fcf387424ce2,
title = "Animal Models of Alzheimer's Disease",
abstract = "Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition.",
keywords = "Alzheimer's disease, Animal models, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, Mouse, Mus musculus, Rat, Rattus norvegicus, Transgenic, Zebrafish",
author = "Morgan Newman and Doris Kretzschmar and Imran Khan and Mengqi Chen and Giuseppe Verdile and Michael Lardelli",
year = "2017",
month = "6",
day = "28",
doi = "10.1016/B978-0-12-809468-6.00040-1",
language = "English",
isbn = "9780128094686",
pages = "1031--1085",
booktitle = "Animal Models for the Study of Human Disease",
publisher = "Academic Press",
address = "United Kingdom",
edition = "2nd",

}

Newman, M, Kretzschmar, D, Khan, I, Chen, M, Verdile, G & Lardelli, M 2017, Animal Models of Alzheimer's Disease. in Animal Models for the Study of Human Disease. 2nd edn, Academic Press, pp. 1031-1085. https://doi.org/10.1016/B978-0-12-809468-6.00040-1

Animal Models of Alzheimer's Disease. / Newman, Morgan; Kretzschmar, Doris; Khan, Imran; Chen, Mengqi; Verdile, Giuseppe; Lardelli, Michael.

Animal Models for the Study of Human Disease. 2nd. ed. Academic Press, 2017. p. 1031-1085.

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - Animal Models of Alzheimer's Disease

AU - Newman, Morgan

AU - Kretzschmar, Doris

AU - Khan, Imran

AU - Chen, Mengqi

AU - Verdile, Giuseppe

AU - Lardelli, Michael

PY - 2017/6/28

Y1 - 2017/6/28

N2 - Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition.

AB - Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition.

KW - Alzheimer's disease

KW - Animal models

KW - Caenorhabditis elegans

KW - Danio rerio

KW - Drosophila melanogaster

KW - Mouse

KW - Mus musculus

KW - Rat

KW - Rattus norvegicus

KW - Transgenic

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85032660628&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-809468-6.00040-1

DO - 10.1016/B978-0-12-809468-6.00040-1

M3 - Chapter

SN - 9780128094686

SP - 1031

EP - 1085

BT - Animal Models for the Study of Human Disease

PB - Academic Press

ER -

Newman M, Kretzschmar D, Khan I, Chen M, Verdile G, Lardelli M. Animal Models of Alzheimer's Disease. In Animal Models for the Study of Human Disease. 2nd ed. Academic Press. 2017. p. 1031-1085 https://doi.org/10.1016/B978-0-12-809468-6.00040-1