Animal Models for the Study of Neonatal Disease

Jean Paul Praud, Yuichiro Miura, Martin G. Frasch

Research output: Chapter in Book/Conference paperChapter

Abstract

Neonatal diseases are quite unique among human diseases because (1) there is a dramatic physiological transition from fetal to neonatal life, (2) organs are still in their developmental stage, and (3) fetuses are affected by the condition of uterine environment, such as intrauterine infection/inflammation. Some characteristics of the diseases have been changed in the past several decades by the elevation of the degree of prematurity owing to the progress of neonatal intensive care. Animal models of the diseases including pregnant dams, neonates, and even adult animals have contributed to the progress of understanding the mechanisms and exploring the efficient treatment strategies, such as antenatal glucocorticoids or neuroprotective hypothermia. In this chapter, the most common neonatal diseases and their corresponding animal models are discussed. We focused on (1) respiratory distress syndrome, (2) chronic lung disease, (3) patent ductus arteriosus, (4) retinopathy of prematurity, (5) intraventricular hemorrhage, (6) cerebral palsy, and (7) necrotizing enterocolitis.

Original languageEnglish
Title of host publicationAnimal Models for the Study of Human Disease
Place of PublicationUnited States
PublisherAcademic Press
Chapter31
Pages805-837
Number of pages33
Edition2nd
ISBN (Electronic)9780124158948
ISBN (Print)9780128094686
DOIs
Publication statusPublished - 28 Jun 2017

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