Animal Models for the Study of Neonatal Disease

Jean Paul Praud, Yuichiro Miura, Martin G. Frasch

Research output: Chapter in Book/Conference paperChapter

Abstract

Neonatal diseases are quite unique among human diseases because (1) there is a dramatic physiological transition from fetal to neonatal life, (2) organs are still in their developmental stage, and (3) fetuses are affected by the condition of uterine environment, such as intrauterine infection/inflammation. Some characteristics of the diseases have been changed in the past several decades by the elevation of the degree of prematurity owing to the progress of neonatal intensive care. Animal models of the diseases including pregnant dams, neonates, and even adult animals have contributed to the progress of understanding the mechanisms and exploring the efficient treatment strategies, such as antenatal glucocorticoids or neuroprotective hypothermia. In this chapter, the most common neonatal diseases and their corresponding animal models are discussed. We focused on (1) respiratory distress syndrome, (2) chronic lung disease, (3) patent ductus arteriosus, (4) retinopathy of prematurity, (5) intraventricular hemorrhage, (6) cerebral palsy, and (7) necrotizing enterocolitis.

Original languageEnglish
Title of host publicationAnimal Models for the Study of Human Disease
Place of PublicationUnited States
PublisherAcademic Press
Chapter31
Pages805-837
Number of pages33
Edition2nd
ISBN (Electronic)9780124158948
ISBN (Print)9780128094686
DOIs
Publication statusPublished - 28 Jun 2017

Fingerprint

Infant, Newborn, Diseases
Animal Models
Neonatal Intensive Care
Animal Disease Models
Retinopathy of Prematurity
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Cerebral Palsy
Hypothermia
Glucocorticoids
Lung Diseases
Fetus
Chronic Disease
Hemorrhage
Inflammation
Infection
Therapeutics

Cite this

Praud, J. P., Miura, Y., & Frasch, M. G. (2017). Animal Models for the Study of Neonatal Disease. In Animal Models for the Study of Human Disease (2nd ed., pp. 805-837). United States: Academic Press. https://doi.org/10.1016/B978-0-12-809468-6.00031-0
Praud, Jean Paul ; Miura, Yuichiro ; Frasch, Martin G. / Animal Models for the Study of Neonatal Disease. Animal Models for the Study of Human Disease. 2nd. ed. United States : Academic Press, 2017. pp. 805-837
@inbook{751e3a373a3147de82ff318cd2d2610a,
title = "Animal Models for the Study of Neonatal Disease",
abstract = "Neonatal diseases are quite unique among human diseases because (1) there is a dramatic physiological transition from fetal to neonatal life, (2) organs are still in their developmental stage, and (3) fetuses are affected by the condition of uterine environment, such as intrauterine infection/inflammation. Some characteristics of the diseases have been changed in the past several decades by the elevation of the degree of prematurity owing to the progress of neonatal intensive care. Animal models of the diseases including pregnant dams, neonates, and even adult animals have contributed to the progress of understanding the mechanisms and exploring the efficient treatment strategies, such as antenatal glucocorticoids or neuroprotective hypothermia. In this chapter, the most common neonatal diseases and their corresponding animal models are discussed. We focused on (1) respiratory distress syndrome, (2) chronic lung disease, (3) patent ductus arteriosus, (4) retinopathy of prematurity, (5) intraventricular hemorrhage, (6) cerebral palsy, and (7) necrotizing enterocolitis.",
keywords = "Cerebral palsy, Chronic lung disease, Intraventricular hemorrhage, Necrotizing enterocolitis, Patent ductus arteriosus, Retinopathy of prematurity",
author = "Praud, {Jean Paul} and Yuichiro Miura and Frasch, {Martin G.}",
year = "2017",
month = "6",
day = "28",
doi = "10.1016/B978-0-12-809468-6.00031-0",
language = "English",
isbn = "9780128094686",
pages = "805--837",
booktitle = "Animal Models for the Study of Human Disease",
publisher = "Academic Press",
address = "United Kingdom",
edition = "2nd",

}

Praud, JP, Miura, Y & Frasch, MG 2017, Animal Models for the Study of Neonatal Disease. in Animal Models for the Study of Human Disease. 2nd edn, Academic Press, United States, pp. 805-837. https://doi.org/10.1016/B978-0-12-809468-6.00031-0

Animal Models for the Study of Neonatal Disease. / Praud, Jean Paul; Miura, Yuichiro; Frasch, Martin G.

Animal Models for the Study of Human Disease. 2nd. ed. United States : Academic Press, 2017. p. 805-837.

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - Animal Models for the Study of Neonatal Disease

AU - Praud, Jean Paul

AU - Miura, Yuichiro

AU - Frasch, Martin G.

PY - 2017/6/28

Y1 - 2017/6/28

N2 - Neonatal diseases are quite unique among human diseases because (1) there is a dramatic physiological transition from fetal to neonatal life, (2) organs are still in their developmental stage, and (3) fetuses are affected by the condition of uterine environment, such as intrauterine infection/inflammation. Some characteristics of the diseases have been changed in the past several decades by the elevation of the degree of prematurity owing to the progress of neonatal intensive care. Animal models of the diseases including pregnant dams, neonates, and even adult animals have contributed to the progress of understanding the mechanisms and exploring the efficient treatment strategies, such as antenatal glucocorticoids or neuroprotective hypothermia. In this chapter, the most common neonatal diseases and their corresponding animal models are discussed. We focused on (1) respiratory distress syndrome, (2) chronic lung disease, (3) patent ductus arteriosus, (4) retinopathy of prematurity, (5) intraventricular hemorrhage, (6) cerebral palsy, and (7) necrotizing enterocolitis.

AB - Neonatal diseases are quite unique among human diseases because (1) there is a dramatic physiological transition from fetal to neonatal life, (2) organs are still in their developmental stage, and (3) fetuses are affected by the condition of uterine environment, such as intrauterine infection/inflammation. Some characteristics of the diseases have been changed in the past several decades by the elevation of the degree of prematurity owing to the progress of neonatal intensive care. Animal models of the diseases including pregnant dams, neonates, and even adult animals have contributed to the progress of understanding the mechanisms and exploring the efficient treatment strategies, such as antenatal glucocorticoids or neuroprotective hypothermia. In this chapter, the most common neonatal diseases and their corresponding animal models are discussed. We focused on (1) respiratory distress syndrome, (2) chronic lung disease, (3) patent ductus arteriosus, (4) retinopathy of prematurity, (5) intraventricular hemorrhage, (6) cerebral palsy, and (7) necrotizing enterocolitis.

KW - Cerebral palsy

KW - Chronic lung disease

KW - Intraventricular hemorrhage

KW - Necrotizing enterocolitis

KW - Patent ductus arteriosus

KW - Retinopathy of prematurity

UR - http://www.scopus.com/inward/record.url?scp=85032704716&partnerID=8YFLogxK

UR - https://www-sciencedirect-com.ezproxy.library.uwa.edu.au/science/book/9780124158948#book-info

U2 - 10.1016/B978-0-12-809468-6.00031-0

DO - 10.1016/B978-0-12-809468-6.00031-0

M3 - Chapter

SN - 9780128094686

SP - 805

EP - 837

BT - Animal Models for the Study of Human Disease

PB - Academic Press

CY - United States

ER -

Praud JP, Miura Y, Frasch MG. Animal Models for the Study of Neonatal Disease. In Animal Models for the Study of Human Disease. 2nd ed. United States: Academic Press. 2017. p. 805-837 https://doi.org/10.1016/B978-0-12-809468-6.00031-0