Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Louisa A. Ho, Colin L. Raston, Keith A. Stubbs

Research output: Contribution to journalArticle

5 Citations (Scopus)
230 Downloads (Pure)

Abstract

The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A3-coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A3-coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

Original languageEnglish
Pages (from-to)8869-8874
Number of pages6
JournalChemistry - A European Journal
Volume24
Issue number35
DOIs
Publication statusPublished - 21 Jun 2018

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