Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus

P.H. Gallego; N. Shephard; M.K. Bulsara; Frank Van Bockxmeer; B.L. Powell; J.P. Beilby; G. Arscott; M. Le Page; Lyle Palmer; Elizabeth Davis; Timothy Jones; Catherine Choong

doi:10.1016/j.jdiacomp.2007.03.003

Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus

P.H. Gallego, N. Shephard, M.K. Bulsara, Frank Van Bockxmeer, B.L. Powell, J.P. Beilby, G. Arscott, M. Le Page, Lyle Palmer, Elizabeth Davis, Timothy Jones, Catherine Choong

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Aim: We examined genetic polymorphisms in the renin-angiotensin system (RAS) coding for angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods: Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9-18.3); diabetes duration, 6.9 years (3.3-10.8); age at diagnosis, 9.1 years (5.8-11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of >= 20 and

Original language	English
Pages (from-to)	191-198
Journal	Journal of Diabetes and Its Complications
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.jdiacomp.2007.03.003
Publication status	Published - 2008

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Gallego, P. H., Shephard, N., Bulsara, M. K., Van Bockxmeer, F., Powell, B. L., Beilby, J. P., Arscott, G., Le Page, M., Palmer, L., Davis, E., Jones, T., & Choong, C. (2008). Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus. Journal of Diabetes and Its Complications, 22(3), 191-198. https://doi.org/10.1016/j.jdiacomp.2007.03.003

Gallego, P.H. ; Shephard, N. ; Bulsara, M.K. ; Van Bockxmeer, Frank ; Powell, B.L. ; Beilby, J.P. ; Arscott, G. ; Le Page, M. ; Palmer, Lyle ; Davis, Elizabeth ; Jones, Timothy ; Choong, Catherine. / Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus. In: Journal of Diabetes and Its Complications. 2008 ; Vol. 22, No. 3. pp. 191-198.

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title = "Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus",

abstract = "Aim: We examined genetic polymorphisms in the renin-angiotensin system (RAS) coding for angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods: Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9-18.3); diabetes duration, 6.9 years (3.3-10.8); age at diagnosis, 9.1 years (5.8-11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of >= 20 and",

author = "P.H. Gallego and N. Shephard and M.K. Bulsara and {Van Bockxmeer}, Frank and B.L. Powell and J.P. Beilby and G. Arscott and {Le Page}, M. and Lyle Palmer and Elizabeth Davis and Timothy Jones and Catherine Choong",

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Gallego, PH, Shephard, N, Bulsara, MK, Van Bockxmeer, F, Powell, BL, Beilby, JP, Arscott, G, Le Page, M, Palmer, L, Davis, E , Jones, T & Choong, C 2008, 'Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus', Journal of Diabetes and Its Complications, vol. 22, no. 3, pp. 191-198. https://doi.org/10.1016/j.jdiacomp.2007.03.003

Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus. / Gallego, P.H.; Shephard, N.; Bulsara, M.K.; Van Bockxmeer, Frank; Powell, B.L.; Beilby, J.P.; Arscott, G.; Le Page, M.; Palmer, Lyle; Davis, Elizabeth ; Jones, Timothy ; Choong, Catherine.

In: Journal of Diabetes and Its Complications, Vol. 22, No. 3, 2008, p. 191-198.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus

AU - Gallego, P.H.

AU - Shephard, N.

AU - Bulsara, M.K.

AU - Van Bockxmeer, Frank

AU - Powell, B.L.

AU - Beilby, J.P.

AU - Arscott, G.

AU - Le Page, M.

AU - Palmer, Lyle

AU - Davis, Elizabeth

AU - Jones, Timothy

AU - Choong, Catherine

PY - 2008

Y1 - 2008

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AB - Aim: We examined genetic polymorphisms in the renin-angiotensin system (RAS) coding for angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods: Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9-18.3); diabetes duration, 6.9 years (3.3-10.8); age at diagnosis, 9.1 years (5.8-11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of >= 20 and

U2 - 10.1016/j.jdiacomp.2007.03.003

DO - 10.1016/j.jdiacomp.2007.03.003

M3 - Article

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EP - 198

JO - Journal of Diabetes and Its Complications

JF - Journal of Diabetes and Its Complications

SN - 1056-8727

IS - 3

ER -