Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus

P.H. Gallego, N. Shephard, M.K. Bulsara, Frank Van Bockxmeer, B.L. Powell, J.P. Beilby, G. Arscott, M. Le Page, Lyle Palmer, Elizabeth Davis, Timothy Jones, Catherine Choong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: We examined genetic polymorphisms in the renin-angiotensin system (RAS) coding for angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods: Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9-18.3); diabetes duration, 6.9 years (3.3-10.8); age at diagnosis, 9.1 years (5.8-11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of >= 20 and
Original languageEnglish
Pages (from-to)191-198
JournalJournal of Diabetes and Its Complications
Volume22
Issue number3
DOIs
Publication statusPublished - 2008

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