Angiogenic factors in bone local environment

Shek Chim, Jennifer Tickner, Siu To Chow, V. Kuek, B. Guo, G. Zhang, V. Rosen, Wendy Erber, Jiake Xu

    Research output: Contribution to journalReview article

    101 Citations (Scopus)

    Abstract

    Angiogenesis plays an important role in physiological bone growth and remodeling, as well as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor metastasis to bone. Vascularization is required for bone remodeling along the endosteal surface of trabecular bone or Haversian canals within the cortical bone, as well as the homeostasis of the cartilage-subchondral bone interface. Angiogenic factors, produced by cells from a basic multicellular unit (BMU) within the bone remodeling compartment (BRC) regulate local endothelial cells and pericytes. In this review, we discuss the expression and function of angiogenic factors produced by osteoclasts, osteoblasts and osteocytes in the BMU and in the cartilage-subchondral bone interface. These include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), BMP7, receptor activator of NF-κB ligand (RANKL) and epidermal growth factor (EGF)-like family members. In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis. Understanding the role of angiogenic factors in the bone microenvironment may help to develop novel therapeutic targets and diagnostic biomarkers for bone and joint diseases, such as osteoporosis, osteonecrosis, osteoarthritis, and delayed fracture healing. © 2013 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)297-310
    JournalCytokine and Growth Factor Reviews
    Volume24
    Issue number3
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Angiogenesis Inducing Agents
    Bone
    Bone and Bones
    Bone Remodeling
    Osteonecrosis
    Cartilage
    Haversian System
    Osteocytes
    Fibroblast Growth Factor Receptors
    Pericytes
    Fracture Healing
    Joint Diseases
    Bone Diseases
    Bone Development
    Fibroblast Growth Factor 2
    Osteoclasts
    Osteoblasts
    Epidermal Growth Factor
    Osteoarthritis
    Vascular Endothelial Growth Factor A

    Cite this

    Chim, Shek ; Tickner, Jennifer ; Chow, Siu To ; Kuek, V. ; Guo, B. ; Zhang, G. ; Rosen, V. ; Erber, Wendy ; Xu, Jiake. / Angiogenic factors in bone local environment. In: Cytokine and Growth Factor Reviews. 2013 ; Vol. 24, No. 3. pp. 297-310.
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    abstract = "Angiogenesis plays an important role in physiological bone growth and remodeling, as well as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor metastasis to bone. Vascularization is required for bone remodeling along the endosteal surface of trabecular bone or Haversian canals within the cortical bone, as well as the homeostasis of the cartilage-subchondral bone interface. Angiogenic factors, produced by cells from a basic multicellular unit (BMU) within the bone remodeling compartment (BRC) regulate local endothelial cells and pericytes. In this review, we discuss the expression and function of angiogenic factors produced by osteoclasts, osteoblasts and osteocytes in the BMU and in the cartilage-subchondral bone interface. These include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), BMP7, receptor activator of NF-κB ligand (RANKL) and epidermal growth factor (EGF)-like family members. In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis. Understanding the role of angiogenic factors in the bone microenvironment may help to develop novel therapeutic targets and diagnostic biomarkers for bone and joint diseases, such as osteoporosis, osteonecrosis, osteoarthritis, and delayed fracture healing. {\circledC} 2013 Elsevier Ltd.",
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    Angiogenic factors in bone local environment. / Chim, Shek; Tickner, Jennifer; Chow, Siu To ; Kuek, V.; Guo, B.; Zhang, G.; Rosen, V.; Erber, Wendy; Xu, Jiake.

    In: Cytokine and Growth Factor Reviews, Vol. 24, No. 3, 2013, p. 297-310.

    Research output: Contribution to journalReview article

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    AU - Chim, Shek

    AU - Tickner, Jennifer

    AU - Chow, Siu To

    AU - Kuek, V.

    AU - Guo, B.

    AU - Zhang, G.

    AU - Rosen, V.

    AU - Erber, Wendy

    AU - Xu, Jiake

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    AB - Angiogenesis plays an important role in physiological bone growth and remodeling, as well as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor metastasis to bone. Vascularization is required for bone remodeling along the endosteal surface of trabecular bone or Haversian canals within the cortical bone, as well as the homeostasis of the cartilage-subchondral bone interface. Angiogenic factors, produced by cells from a basic multicellular unit (BMU) within the bone remodeling compartment (BRC) regulate local endothelial cells and pericytes. In this review, we discuss the expression and function of angiogenic factors produced by osteoclasts, osteoblasts and osteocytes in the BMU and in the cartilage-subchondral bone interface. These include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), BMP7, receptor activator of NF-κB ligand (RANKL) and epidermal growth factor (EGF)-like family members. In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis. Understanding the role of angiogenic factors in the bone microenvironment may help to develop novel therapeutic targets and diagnostic biomarkers for bone and joint diseases, such as osteoporosis, osteonecrosis, osteoarthritis, and delayed fracture healing. © 2013 Elsevier Ltd.

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