Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM

M.A. Degli-Esposti, L.J. Abraham, V. Mccann, T. Spies, Frank Christiansen, R.L. Dawkins

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    104 Citations (Scopus)

    Abstract

    The major histocompatibility complex (MHC) contains multiple and diverse genes which may be relevant to the induction and regulation of autoimmune responses in insulin dependent diabetes mellitus (IDDM). In addition to HLA class I and II, the possible candidates include TNF, C4, and several other poorly defined polymorphic genes in the central MHC region. This study describes two approaches which take advantage of the fact that the relevant genes are carried by highly conserved ancestral haplotypes such as 8.1 (HLA-B8, TNFS, C4AQ0, C4B1, DR3, DQ2). First, three "diabetogenic" haplotypes (two Caucasoid and one Mongoloid) have been compared and it has been shown that all three share a rare allele of BAT3 as well as sharing DR3, DQ2. In 43 sequential patients with IDDM the cross product ratio for BAT3S was 4.8 (p
    Original languageEnglish
    Pages (from-to)345-356
    JournalImmunogenetics
    Volume36
    Publication statusPublished - 1992

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