Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

Matt S. Hepburn, Philip Wijesinghe, Lixin Chin, Brendan F. Kennedy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution in compression OCE is both spatially varying and sample dependent, which we link to the discrepancies between the model of elasticity and the mechanical deformation of the sample. We demonstrate that resolution is dependent on factors such as feature size and mechanical contrast. We believe that the analysis of image formation provided by our framework can expedite the development of compression OCE. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Original languageEnglish
Pages (from-to)1496-1513
Number of pages18
JournalBiomedical Optics Express
Volume10
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Cite this

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Analysis of spatial resolution in phase-sensitive compression optical coherence elastography. / Hepburn, Matt S.; Wijesinghe, Philip; Chin, Lixin; Kennedy, Brendan F.

In: Biomedical Optics Express, Vol. 10, No. 3, 01.03.2019, p. 1496-1513.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

AU - Hepburn, Matt S.

AU - Wijesinghe, Philip

AU - Chin, Lixin

AU - Kennedy, Brendan F.

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AB - Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution in compression OCE is both spatially varying and sample dependent, which we link to the discrepancies between the model of elasticity and the mechanical deformation of the sample. We demonstrate that resolution is dependent on factors such as feature size and mechanical contrast. We believe that the analysis of image formation provided by our framework can expedite the development of compression OCE. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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KW - DIFFERENTIATION

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