Analysis of post-transcriptional and architectural regulatory mechanisms controlling complement receptor gene expression in B cells

Research output: ThesisDoctoral Thesis

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Abstract

The regulators of complement activation (RCA) cluster on human chromosome 1 contains several functionally related genes whose products play crucial roles in the regulation of complement-mediated immune pathways. Many of these genes, such as complement receptor 2 (CR2), have been associated with the autoimmune disease systemic lupus erythematosus (SLE). We used chromosome conformation capture techniques to identify genomic interactions across the RCA gene cluster and characterised potential enhancers for CR2 in B cells. We also identified CR2 as a microRNA target and characterised the regulation and expression of several microRNAs important in B cell development.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date13 Aug 2018
DOIs
Publication statusUnpublished - 2018

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