Analysis of Cytotoxic Effects of Zerumbone in Malignant Glioblastoma Cells

Mohammad Jalili-Nik, Amir R. Afshari, Khadijeh Mahboobnia, Paul C. Guest, Tannaz Jamialahmadi, Amirhossein Sahebkar

Research output: Chapter in Book/Conference paperChapterpeer-review

Abstract

Glioblastoma multiforme (GBM) is an aggressive tumor in the central nervous system with a poor prognosis. Currently, the main interventions include surgery, chemotherapy, and radiotherapy. Recently, several natural products have been reported as potentially effective and safer treatment options. Here, we studied the effects of zerumbone, a sesquiterpene compound derived from Zingiber zerumbet Smith rhizomes, on human GBM U-87 MG cells in vitro. To meet this purpose, we used a cytotoxicity assay, as well as a quantitative polymerase chain reaction of apoptosis-related genes and western blot analysis of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a transcription factor that controls the production of cytokines and molecules involved in cell survival.

Original languageEnglish
Title of host publicationPhysical Exercise and Natural and Synthetic Products in Health and Disease
EditorsPaul C. Guest
PublisherHumana Press
Pages361-369
Number of pages9
Volume2343
Edition2022
ISBN (Electronic)978-1-0716-1558-4
ISBN (Print)978-1-0716-1557-7
DOIs
Publication statusPublished - 2022
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2343
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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