TY - JOUR
T1 - An urgent need for African spirometry reference equations
T2 - The Paediatric and Adult African Spirometry study
AU - Masekela, R.
AU - Hall, G. L.
AU - Stanojevic, S.
AU - Sartorius, B.
AU - MacGinty, R.
AU - Benn Saad, H.
AU - Trabelsi, Y.
AU - Messan, F.
AU - Arigliani, M.
AU - Ketfi, A.
AU - Gray, Diane M.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - BACKGROUND: The GLI2012 (Global Lung Initiative 2012) has provided the largest data set to date for multiethnic spirometry reference equations; however, data on African populations are limited. In pulmonary function testing, diagnosis of lung disorder is based on comparing the individual's lung function to a reference appropriate for sex and ethnicity. ME T HODS : We conducted a systematic review of studies reporting spirometry results in healthy children and adults in Africa. Data from these studies were collated for Z-scores of forced expiratory volume in 1 sec (zFEV1), forced vital capacity (zFVC) and zFEV1/ FVC compared to GLI reference equations. RESULT S : Nine studies, covering a total of 4750 individuals from North, South, East,West and Central Africa (52% were female), were reviewed. Marked differences were noted between individuals from North Africa and sub-Saharan Africa. The Southern zFEV1 (-0.12 ± 0.98), zFVC (-0.15 ± 0.98) and zFEV1/FVC (0.05 ± 0.89), Central zFEV1 (-0.16 ± 0.79), zFVC (-0.09 ± 0.83) and zFEV1/FVC (-0.17 ± 0.71) and East African zFEV1 (0.10 ± 0.88), zFVC (0.16 ± 0.85) and zFEV1/FVC (-0.10 ± 0.95) cohorts had an excellent fit with the GLI-African American. The West African showed a poor fit to all reference equations. The North African group showed the best fit for the GLI Caucasian zFEV1 (-0.12 ± 1.37), zFVC (-0.26 ± 1.36) and zFEV1/FVC (0.25 ± 1.11). The zFEV1/FVC ratios were stable across all the populations. CONCLUS ION: Current evidence seems to support the use of GLI2012 reference values in North African and sub-Saharan African populations after taking into account ethnic correction factors.
AB - BACKGROUND: The GLI2012 (Global Lung Initiative 2012) has provided the largest data set to date for multiethnic spirometry reference equations; however, data on African populations are limited. In pulmonary function testing, diagnosis of lung disorder is based on comparing the individual's lung function to a reference appropriate for sex and ethnicity. ME T HODS : We conducted a systematic review of studies reporting spirometry results in healthy children and adults in Africa. Data from these studies were collated for Z-scores of forced expiratory volume in 1 sec (zFEV1), forced vital capacity (zFVC) and zFEV1/ FVC compared to GLI reference equations. RESULT S : Nine studies, covering a total of 4750 individuals from North, South, East,West and Central Africa (52% were female), were reviewed. Marked differences were noted between individuals from North Africa and sub-Saharan Africa. The Southern zFEV1 (-0.12 ± 0.98), zFVC (-0.15 ± 0.98) and zFEV1/FVC (0.05 ± 0.89), Central zFEV1 (-0.16 ± 0.79), zFVC (-0.09 ± 0.83) and zFEV1/FVC (-0.17 ± 0.71) and East African zFEV1 (0.10 ± 0.88), zFVC (0.16 ± 0.85) and zFEV1/FVC (-0.10 ± 0.95) cohorts had an excellent fit with the GLI-African American. The West African showed a poor fit to all reference equations. The North African group showed the best fit for the GLI Caucasian zFEV1 (-0.12 ± 1.37), zFVC (-0.26 ± 1.36) and zFEV1/FVC (0.25 ± 1.11). The zFEV1/FVC ratios were stable across all the populations. CONCLUS ION: Current evidence seems to support the use of GLI2012 reference values in North African and sub-Saharan African populations after taking into account ethnic correction factors.
KW - Africa
KW - Global lung initiative
KW - Healthy
KW - Lung function
KW - Population
UR - http://www.scopus.com/inward/record.url?scp=85068411391&partnerID=8YFLogxK
U2 - 10.5588/ijtld.18.0442
DO - 10.5588/ijtld.18.0442
M3 - Article
C2 - 31533886
AN - SCOPUS:85068411391
SN - 1027-3719
VL - 23
SP - 952
EP - 958
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 8
ER -