Projects per year
Abstract
The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable.
Original language | English |
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Article number | 22595 |
Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Scientific Reports |
Volume | 6 |
DOIs | |
Publication status | Published - 4 Mar 2016 |
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Nanotechnology to stop the spread of damage after brain injury
Dunlop, S. (Investigator 01), Fitzgerald, M. (Investigator 02), Swaminatha Iyer, I. (Investigator 03) & Hool, L. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research
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Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma
Fitzgerald, M. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/15 → 30/12/18
Project: Research