@article{7fbfc26d136c4443b4dcd4ad77b56528,
title = "An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA",
abstract = "Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilageĝ€{"}hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.",
author = "Yoshiko Maida and Mami Yasukawa and Miho Furuuchi and Timo Lassmann and Richard Possemato and Naoko Okamoto and Vivi Kasim and Yoshihide Hayashizaki and Hahn, {William C.} and Kenkichi Masutomi",
note = "Funding Information: Acknowledgements We thank T. Sugimura and S. Hirohashi at the National Cancer Center for comments. We also thank H. Siomi, H. Tabara and Y. Tomari for discussions. This work was supported in part by Grant-in-Aid for Young Scientists (A) 19689010 (K.M.) and Grant-in-Aid for Young Scientists (B) 19791141 (Y.M.) from the Ministry of Education, Culture, Sports, Science and Technology, by the Third-Term Comprehensive Control Research for Cancer (K.M.) from the Ministry of Health, Labor, and Welfare, by a Takeda Science Foundation grant (K.M.), the Uehara Memorial Foundation (K.M.), a J&J Focused Funding Award (W.C.H.) and R01 AG23145 from the National Institutes of Health (W.C.H.).",
year = "2009",
month = sep,
day = "10",
doi = "10.1038/nature08283",
language = "English",
volume = "461",
pages = "230--235",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "7261",
}