Projects per year
Abstract
Cyclic peptides are abundant in plants and have attracted interest due to their bioactivity and potential as drug scaffolds. Orbitides are head-to-tail cyclic peptides that are ribosomally synthesized, post-translationally modified, and lack disulfide bonds. All known orbitides contain 5-12 amino acid residues. Here we describe PLP-53, a novel orbitide from the seed of Ratibida columnifera. PLP-53 consists of 16 amino acids, four residues larger than any known orbitide. NMR structural studies showed that, compared to previously characterized orbitides, PLP-53 is more flexible and, under the studied conditions, did not adopt a single ordered conformation based on analysis of NOEs and chemical shifts.
Original language | English |
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Journal | Journal of Natural Products |
DOIs | |
Publication status | E-pub ahead of print - 8 Aug 2019 |
Fingerprint Dive into the research topics of 'An orbitide from <i>Ratibida columnifera </i>seed containing 16 amino acid residues'. Together they form a unique fingerprint.
Projects
- 1 Active
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Buried treasure: bioactive plant seed proteins evolving inside hosts
Mylne, J., Rosengren, K., van der Hoorn, R. & Hara-Nishimura, I.
1/01/19 → 31/12/21
Project: Research