An orbitide from Ratibida columnifera seed containing 16 amino acid residues

Mark F. Fisher, Colton D. Payne, K. Johan Rosengren, Joshua S Mylne

Research output: Contribution to journalArticle

4 Citations (Scopus)
8 Downloads (Pure)


Cyclic peptides are abundant in plants and have attracted interest due to their bioactivity and potential as drug scaffolds. Orbitides are head-to-tail cyclic peptides that are ribosomally synthesized, post-translationally modified, and lack disulfide bonds. All known orbitides contain 5-12 amino acid residues. Here we describe PLP-53, a novel orbitide from the seed of Ratibida columnifera. PLP-53 consists of 16 amino acids, four residues larger than any known orbitide. NMR structural studies showed that, compared to previously characterized orbitides, PLP-53 is more flexible and, under the studied conditions, did not adopt a single ordered conformation based on analysis of NOEs and chemical shifts.

Original languageEnglish
JournalJournal of Natural Products
Publication statusE-pub ahead of print - 8 Aug 2019

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