An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

M.G. Carolan; B.M. Oborn; K. Foo; A. Haworth; S.L. Gulliford; Martin Ebert

doi:10.1088/1742-6596/489/1/012087

An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

M.G. Carolan, B.M. Oborn, K. Foo, A. Haworth, S.L. Gulliford, Martin Ebert

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

3 Citations (Scopus)

Abstract

The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. © Published under licence by IOP Publishing Ltd.

Original language	English
Title of host publication	An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates
Publisher	IOP Publishing
Pages	012087
Volume	489
ISBN (Print)	17426588
DOIs	https://doi.org/10.1088/1742-6596/489/1/012087
Publication status	Published - 2014
Event	17th International Conference on the Use of Computers in Radiation Therapy - Melbourne, Australia Duration: 6 May 2013 → 9 May 2013

Publication series

Name	Journal of Physics: Conference Series

Conference

Conference	17th International Conference on the Use of Computers in Radiation Therapy
Country/Territory	Australia
City	Melbourne
Period	6/05/13 → 9/05/13

Access to Document

10.1088/1742-6596/489/1/012087

Cite this

Carolan, M. G., Oborn, B. M., Foo, K., Haworth, A., Gulliford, S. L., & Ebert, M. (2014). An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. In An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates (Vol. 489, pp. 012087). (Journal of Physics: Conference Series). IOP Publishing. https://doi.org/10.1088/1742-6596/489/1/012087

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title = "An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates",

abstract = "The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. {\textcopyright} Published under licence by IOP Publishing Ltd.",

author = "M.G. Carolan and B.M. Oborn and K. Foo and A. Haworth and S.L. Gulliford and Martin Ebert",

year = "2014",

doi = "10.1088/1742-6596/489/1/012087",

language = "English",

isbn = "17426588",

volume = "489",

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pages = "012087",

booktitle = "An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates",

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note = "17th International Conference on the Use of Computers in Radiation Therapy ; Conference date: 06-05-2013 Through 09-05-2013",

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Carolan, MG, Oborn, BM, Foo, K, Haworth, A, Gulliford, SL & Ebert, M 2014, An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. in An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. vol. 489, Journal of Physics: Conference Series, IOP Publishing, pp. 012087, 17th International Conference on the Use of Computers in Radiation Therapy, Melbourne, Victoria, Australia, 6/05/13. https://doi.org/10.1088/1742-6596/489/1/012087

An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. / Carolan, M.G.; Oborn, B.M.; Foo, K. et al.
An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. Vol. 489 IOP Publishing, 2014. p. 012087 (Journal of Physics: Conference Series).

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

TY - GEN

T1 - An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

AU - Carolan, M.G.

AU - Oborn, B.M.

AU - Foo, K.

AU - Haworth, A.

AU - Gulliford, S.L.

AU - Ebert, Martin

PY - 2014

Y1 - 2014

N2 - The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. © Published under licence by IOP Publishing Ltd.

AB - The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. © Published under licence by IOP Publishing Ltd.

U2 - 10.1088/1742-6596/489/1/012087

DO - 10.1088/1742-6596/489/1/012087

M3 - Conference paper

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VL - 489

T3 - Journal of Physics: Conference Series

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BT - An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

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T2 - 17th International Conference on the Use of Computers in Radiation Therapy

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Carolan MG, Oborn BM, Foo K, Haworth A, Gulliford SL, Ebert M. An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. In An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. Vol. 489. IOP Publishing. 2014. p. 012087. (Journal of Physics: Conference Series). doi: 10.1088/1742-6596/489/1/012087

An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

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Conference

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