An investigation of the sterile inflammatory response in cardiac transplantation

Charu Nanayakkara

Research output: ThesisDoctoral Thesis

Abstract

Sterile inflammation is an understudied consequence of solid organ transplantation. In this thesis, time-dependent longitudinal(T0, T1, T7, T30) and conditional (native vs grafted hearts) sterile inflammatory pathways that contribute to the pathogenesis ofacute solid organ rejection were investigated utilising murine models of syngenic and allogenic heterotopic heart transplantation.In both models, inflammation-specific and non-specific cellular changes were identified. While acute allograft rejection wasTh1 driven, allogenic native hearts were protected from bystander cellular infiltration by unknown mechanisms. Key cellularinteractions were condensed into a mathematical model which may help delineate novel therapeutic targets against allograftrejection.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lucas, Michaela, Supervisor
  • Gaudieri, Silvana, Supervisor
  • Kallies, Alex, Supervisor, External person
Thesis sponsors
Award date2 Oct 2022
Publication statusUnpublished - 2022

Embargo information

  • Embargoed from 02/10/2022 to 17/10/2024

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