An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis

Adam Maurice Passman

Research output: ThesisDoctoral Thesis

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Abstract

Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnostic
and future therapeutic developments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Yeoh, George, Supervisor
  • Callus, Bernard, Supervisor
Award date11 Jun 2018
DOIs
Publication statusUnpublished - 2018

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