An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis

Adam Maurice Passman

Research output: ThesisDoctoral Thesis

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Abstract

Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnostic
and future therapeutic developments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Yeoh, George, Supervisor
  • Callus, Bernard, Supervisor
Award date11 Jun 2018
DOIs
Publication statusUnpublished - 2018

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Carcinogenesis
Stem Cells
Liver
Cell- and Tissue-Based Therapy
Population
Neoplasms
Therapeutics

Cite this

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title = "An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis",
abstract = "Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnosticand future therapeutic developments.",
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language = "English",
school = "The University of Western Australia",

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AB - Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnosticand future therapeutic developments.

KW - Liver Progenitor Cell

KW - liver cancer

KW - Hepatocellular carcinoma

KW - Cholangiocarcinoma

KW - Tumorigenicity

KW - Transcriptomics

KW - CDE diet

KW - TP53

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DO - 10.4225/23/5b39980af65d8

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