An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis

Adam Maurice Passman

doi:10.4225/23/5b39980af65d8

An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis

Adam Maurice Passman

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnostic
and future therapeutic developments.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Yeoh, George, Supervisor Callus, Bernard, Supervisor
Award date	11 Jun 2018
DOIs	https://doi.org/10.4225/23/5b39980af65d8
Publication status	Unpublished - 2018

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THESIS - DOCTOR OF PHILOSOPHY - PASSMAN Adam Maurice - 2018
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Cite this

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title = "An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis",

abstract = "Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnosticand future therapeutic developments.",

keywords = "Liver Progenitor Cell, liver cancer, Hepatocellular carcinoma, Cholangiocarcinoma, Tumorigenicity, Transcriptomics, CDE diet, TP53",

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AB - Liver progenitor cells (LPC) propagate to repair chronically damaged livers. They are an attractive candidate for regenerative cell therapy. However, LPCs proliferate within tumorigenic microenvironments and mounting evidence suggests they play a role in liver carcinogenesis. The precise mechanisms causing LPC transformation are unknown, and this knowledge will be useful to identify suitable LPC populations for cell therapy to prevent and treat LPC-related cancer. This thesis investigates means of propagating and characterising LPCs and crucially, it establishes mechanisms of tumorigenicity in LPCs to facilitate diagnosticand future therapeutic developments.

KW - Liver Progenitor Cell

KW - liver cancer

KW - Hepatocellular carcinoma

KW - Cholangiocarcinoma

KW - Tumorigenicity

KW - Transcriptomics

KW - CDE diet

KW - TP53

U2 - 10.4225/23/5b39980af65d8

DO - 10.4225/23/5b39980af65d8

M3 - Doctoral Thesis

ER -

An investigation of liver progenitor cells: Signalling pathways, markers and mechanisms of transformation and tumorigenesis

Abstract

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