An Investigation into the Synthesis of Some Molecules Related to Methyl Acarviosin

M.J. Mcdonough, Robert Stick, Matthew Tilbrook, A.G. Watts

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Methyl acarviosin is an impressive inhibitor of some glycoside hydrolases that process substrates containing alpha-D-glucosidic linkages. In an attempt to provide putative inhibitors for enzymes that process beta-D-glucosidic linkages, we report an improved synthesis of a hydroxylated 'methyl beta-acarviosin' and our efforts towards various deoxygenated versions of methyl beta-acarviosin. As well, the synthesis of a 1,3-linked variant of methyl beta-acarviosin is reported, together with an unsuccessful 'tether' approach to construct the crucial nitrogen linkage in the acarviosins.
Original languageEnglish
Pages (from-to)233-241
JournalAustralian Journal of Chemistry
Volume57
Issue number3
DOIs
Publication statusPublished - 2004

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