Abstract
Clinicians and other decision makers in healthcare use results from clinical trials to inform practice. Interpretation of clinical trial results can be challenging, as weaknesses in trial design, data collection, analysis or reporting, can compromise the usefulness of results. A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches. The focus will be on confirmatory clinical trials.
| Original language | English |
|---|---|
| Journal | Paediatric Respiratory Reviews |
| DOIs | |
| Publication status | Published - 26 Jun 2019 |
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An introduction to clinical trial design. / Schultz, A.; Saville, B. R.; Marsh, J. A.; Snelling, T. L.
In: Paediatric Respiratory Reviews, 26.06.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - An introduction to clinical trial design
AU - Schultz, A.
AU - Saville, B. R.
AU - Marsh, J. A.
AU - Snelling, T. L.
PY - 2019/6/26
Y1 - 2019/6/26
N2 - Clinicians and other decision makers in healthcare use results from clinical trials to inform practice. Interpretation of clinical trial results can be challenging, as weaknesses in trial design, data collection, analysis or reporting, can compromise the usefulness of results. A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches. The focus will be on confirmatory clinical trials.
AB - Clinicians and other decision makers in healthcare use results from clinical trials to inform practice. Interpretation of clinical trial results can be challenging, as weaknesses in trial design, data collection, analysis or reporting, can compromise the usefulness of results. A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches. The focus will be on confirmatory clinical trials.
KW - Adaptive trial design
KW - Clinical trial design
KW - Randomisation
UR - http://www.scopus.com/inward/record.url?scp=85070705763&partnerID=8YFLogxK
U2 - 10.1016/j.prrv.2019.06.002
DO - 10.1016/j.prrv.2019.06.002
M3 - Review article
JO - Paediatric Respiratory Reviews
JF - Paediatric Respiratory Reviews
SN - 1526-0542
ER -