TY - JOUR
T1 - An intrinsically disordered proteins community for elixir [version 1; peer review
T2 - 2 approved]
AU - Davey, Norman E.
AU - Babu, M. Madan
AU - Blackledge, Martin
AU - Bridge, Alan
AU - Capella-Gutierrez, Salvador
AU - Dosztanyi, Zsuzsanna
AU - Drysdale, Rachel
AU - Edwards, Richard J.
AU - Elofsson, Arne
AU - Felli, Isabella C.
AU - Gibson, Toby J.
AU - Gutmanas, Aleksandras
AU - Hancock, John M.
AU - Harrow, Jen
AU - Higgins, Desmond
AU - Jeffries, Cy M.
AU - Le Mercier, Philippe
AU - Meszaros, Balint
AU - Necci, Marco
AU - Notredame, Cedric
AU - Orchard, Sandra
AU - Ouzounis, Christos A.
AU - Pancsa, Rita
AU - Papaleo, Elena
AU - Pierattelli, Roberta
AU - Piovesan, Damiano
AU - Promponas, Vasilis J.
AU - Ruch, Patrick
AU - Rustici, Gabriella
AU - Romero, Pedro
AU - Sarntivijai, Sirarat
AU - Saunders, Gary
AU - Schuler, Benjamin
AU - Sharan, Malvika
AU - Shields, Denis C.
AU - Sussman, Joel L.
AU - Tedds, Jonathan A.
AU - Tompa, Peter
AU - Turewicz, Michael
AU - Vondrasek, Jiri
AU - Vranken, Wim F.
AU - Wallace, Bonnie Ann
AU - Wichapong, Kanin
AU - Tosatto, Silvio C.E.
N1 - Funding Information:
Grant information: A strategic meeting to identify the key priority areas for the roadmap was funded by ELIXIR, the research infrastructure for life-science data. BW was funded by a grant from the BBSRC [BB/P024092/1]. AB, SO and PLM were supported by the National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of General Medical Sciences (NIGMS), and National Institute of Mental Health (NIMH) of the National Institutes of Health under Award Number [U24HG007822] (the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health), by European Molecular Biology Laboratory (EMBL) and by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI. AG was supported by the European Molecular Biology Laboratory (EMBL) and the Wellcome Trust [104948]. AE was supported by a Vetenskapsrådet grant [2016-03798]. EP was supported by Danmarks Grundforskningsfond [DNRF125] and a Carlsberg Foundation Distinguished Fellowship [CF18-0314]. JLS was supported by the Israel I-CORE Project: Integrated Structural Cell Biology and by Instruct-ERIC. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement [778247] and COST Action BM1405 NGP-net.
Publisher Copyright:
© 2019 Davey NE et al.
PY - 2019
Y1 - 2019
N2 - Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled “An intrinsically disordered protein user community proposal for ELIXIR” held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.
AB - Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled “An intrinsically disordered protein user community proposal for ELIXIR” held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.
KW - Cellular regulation
KW - Community standards
KW - Databases
KW - ELIXIR
KW - Intrinsically disordered proteins
KW - Protein dynamics
KW - Protein function
KW - Protein-protein interactions
UR - http://www.scopus.com/inward/record.url?scp=85076296099&partnerID=8YFLogxK
U2 - 10.12688/f1000research.20136.1
DO - 10.12688/f1000research.20136.1
M3 - Article
C2 - 31824649
AN - SCOPUS:85076296099
SN - 2046-1402
VL - 8
JO - F1000Research
JF - F1000Research
M1 - 1753
ER -