An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

Romy Martin; Marta Polomska; Lindsay Byrne; Scott Stewart

doi:10.1016/j.tetlet.2011.07.047

An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

Romy Martin, Marta Polomska, Lindsay Byrne, Scott Stewart

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Abstract

Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4878-4881
Journal	Tetrahedron Letters
Volume	52
DOIs	https://doi.org/10.1016/j.tetlet.2011.07.047
Publication status	Published - 2011

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title = "An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines",

abstract = "Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.",

author = "Romy Martin and Marta Polomska and Lindsay Byrne and Scott Stewart",

year = "2011",

doi = "10.1016/j.tetlet.2011.07.047",

language = "English",

volume = "52",

pages = "4878--4881",

journal = "Tetrahedron Letters",

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T1 - An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

AU - Martin, Romy

AU - Polomska, Marta

AU - Byrne, Lindsay

AU - Stewart, Scott

PY - 2011

Y1 - 2011

N2 - Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

AB - Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2011.07.047

DO - 10.1016/j.tetlet.2011.07.047

M3 - Article

SN - 0040-4039

VL - 52

SP - 4878

EP - 4881

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

Abstract

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