An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

Romy Martin, Marta Polomska, Lindsay Byrne, Scott Stewart

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4878-4881
JournalTetrahedron Letters
Volume52
DOIs
Publication statusPublished - 2011

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