Abstract
Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 4878-4881 |
Journal | Tetrahedron Letters |
Volume | 52 |
DOIs | |
Publication status | Published - 2011 |