Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Martin, R., Polomska, M., Byrne, L., & Stewart, S. (2011). An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines. Tetrahedron Letters, 52, 4878-4881. https://doi.org/10.1016/j.tetlet.2011.07.047