An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas, Davide D'Angella, Jeremy G. Baldwin, Nathan J. Castro, Felix M. Wunner, Navid T. Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher

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30 Citations (Scopus)

Abstract

We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.

Original languageEnglish
Pages (from-to)29430-29437
Number of pages8
JournalACS Applied Materials and Interfaces
Volume9
Issue number35
DOIs
Publication statusPublished - 6 Sep 2017
Externally publishedYes

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Bas, O., D'Angella, D., Baldwin, J. G., Castro, N. J., Wunner, F. M., Saidy, N. T., ... Hutmacher, D. W. (2017). An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues. ACS Applied Materials and Interfaces, 9(35), 29430-29437. https://doi.org/10.1021/acsami.7b08617