@phdthesis{ddcd998d0d194c249b488e50ac92868e,
title = "An in-depth investigation of orexin receptor pharmacology profiled using advanced Bioluminescence Resonance Energy Transfer (BRET) techniques",
abstract = "The orexin system is a hypothalamic modulatory system that regulates arousal states and feeding behaviour. The system comprises two G protein coupled receptors (GPCRs), orexin receptor 1 (OxR1) and orexin receptor 2 (OxR2) and two neuropeptides, orexin A (OxA) and orexin B (OxB). This thesis utilises Bioluminescence Resonance Energy Transfer(BRET) to conduct an in-depth investigation of the pharmacology of the orexin receptors. The results of this thesis show pharmacologically-relevant spatiotemporal control of orexin receptor signalling. These findings warrant further investigation to determine the relevance of these trends to different cell types and small molecule orexin agonists.",
keywords = "BRET, GPCRs, Orexin, Hypocretin, Receptor Signalling, Pharmacology, Receptor Trafficking",
author = "Natasha Dale",
year = "2022",
doi = "10.26182/pa2g-hf60",
language = "English",
school = "The University of Western Australia",
}