An exposome perspective: Early-life events and immune development in a changing world

Harald Renz, Patrick Holt, Michael Inouye, Alan C. Logan, Susan L. Prescott, Peter D. Sly

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system. The result is a transformed view of future prevention and treatment of chronic noncommunicable diseases, including allergy. Paradigm-shifting gains in scientific knowledge are occurring at a time of rapid global environmental change, urbanization, and biodiversity losses. Multifactorial and multigenerational implications of total environmental exposures, the exposome, require coordinated interdisciplinary efforts. It is clear that the genome alone cannot provide answers to urgent questions. Here we review the historical origins of exposome research and define a new concept, the metaexposome, which considers the bidirectional effect of the environment on human subjects and the human influence on all living systems and their genomes. The latter is essential for human health. We place the metaexposome in the context of early-life immune functioning and describe how various aspects of a changing environment, especially through microbiota exposures, can influence health and disease over the life course. Crown Copyright © 2017 Published by Elsevier Inc. on behalf of American Academy of Allergy, Asthma & Immunology. 

Original languageEnglish
Pages (from-to)24-40
Number of pages17
JournalThe Journal of Allergy and Clinical Immunology
Volume140
Issue number1
DOIs
Publication statusPublished - Jul 2017

Cite this

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abstract = "Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system. The result is a transformed view of future prevention and treatment of chronic noncommunicable diseases, including allergy. Paradigm-shifting gains in scientific knowledge are occurring at a time of rapid global environmental change, urbanization, and biodiversity losses. Multifactorial and multigenerational implications of total environmental exposures, the exposome, require coordinated interdisciplinary efforts. It is clear that the genome alone cannot provide answers to urgent questions. Here we review the historical origins of exposome research and define a new concept, the metaexposome, which considers the bidirectional effect of the environment on human subjects and the human influence on all living systems and their genomes. The latter is essential for human health. We place the metaexposome in the context of early-life immune functioning and describe how various aspects of a changing environment, especially through microbiota exposures, can influence health and disease over the life course. Crown Copyright {\circledC} 2017 Published by Elsevier Inc. on behalf of American Academy of Allergy, Asthma & Immunology. ",
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An exposome perspective : Early-life events and immune development in a changing world. / Renz, Harald; Holt, Patrick; Inouye, Michael; Logan, Alan C.; Prescott, Susan L.; Sly, Peter D.

In: The Journal of Allergy and Clinical Immunology, Vol. 140, No. 1, 07.2017, p. 24-40.

Research output: Contribution to journalArticle

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T2 - Early-life events and immune development in a changing world

AU - Renz, Harald

AU - Holt, Patrick

AU - Inouye, Michael

AU - Logan, Alan C.

AU - Prescott, Susan L.

AU - Sly, Peter D.

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KW - vaginal microbiome

KW - inflammation

KW - allergy protection

KW - cytokines

KW - biodiversity

KW - colonization

KW - antibiotics

KW - developmental origins of health and disease

KW - ecosystems

KW - prevention

KW - environmental toxicology

KW - endocrine disrupting chemicals

KW - noncommunicable diseases

KW - HUMAN GUT MICROBIOME

KW - MCMASTER UNIVERSITY GUIDELINES

KW - SYNCYTIAL VIRUS BRONCHIOLITIS

KW - ALLERGIC AIRWAY INFLAMMATION

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KW - 99TH DAHLEM CONFERENCE

KW - SCHOOL-AGE-CHILDREN

KW - TOLL-LIKE RECEPTORS

KW - REGULATORY T-CELLS

KW - INTESTINAL MICROBIOTA

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DO - 10.1016/j.jaci.2017.05.015

M3 - Article

VL - 140

SP - 24

EP - 40

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

SN - 0091-6749

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ER -