An evaluation of four parametric models of contrast enhancement for dynamic magnetic resonance imaging of the breast

Yaniv Gal, Andrew Mehnert, Andrew Bradley, Kerry McMahon, Stuart Crozier

Research output: Chapter in Book/Conference paperConference paper

15 Citations (Scopus)

Abstract

This paper presents an empirical evaluation of the goodness-of-fit (GOF) of four parametric models of contrast enhancement for dynamic resonance imaging of the breast: the Tofts, Brix, and Hayton pharmacokinetic models, and a novel empiric model. The goodness-of-fit of each model was evaluated with respect to: (i) two model-fitting algorithms (Levenberg-Marquardt and Nelder-Mead) and two fitting tolerances; and (ii) temporal resolution. In the first case the GOF was measured using data from three dynamic contrast-enhanced (DCE) MRI data sets from routine clinical examinations: one case with benign enhancement, one with malignant enhancement, and one with normal findings. Results are presented for fits to both the whole breast volume and to a selected region of interest. In the second case the GOF was measured by first fitting the models to several temporally sub-sampled versions of a custom high temporal resolution data set (subset of the breast volume containing a malignant lesion), and then comparing the fitted results to the original full temporal resolution data. Our results demonstrate that under the various optimization conditions considered, in general, both the proposed empiric model and the Hayton model fit the data equally well and that both of these models fit the data better than the Tofts and Brix models.

Original languageEnglish
Title of host publication29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Pages71-74
Number of pages4
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France
Duration: 23 Aug 200726 Aug 2007

Conference

Conference29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CountryFrance
CityLyon
Period23/08/0726/08/07

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