TY - JOUR
T1 - An association of large-fibre peripheral nerve dysfunction with non-invasive measures of liver fibrosis secondary to non-alcoholic fatty liver disease in diabetes
AU - Williams, Kathryn H
AU - Burns, Kharis
AU - Constantino, Maria
AU - Shackel, Nicholas A
AU - Prakoso, Emilia
AU - Wong, Jencia
AU - Wu, Ted
AU - George, Jacob
AU - McCaughan, Geoffrey W
AU - Twigg, Stephen M
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - AIM: To examine for an association of elevated lower-limb vibration perception threshold (VPT) with NAFLD fibrosis.METHODS: Two cohorts from a tertiary diabetes centre were studied - Cohort 1, n=456 with type 1 or 2 diabetes, and Cohort 2, n=106 with type 2 diabetes mellitus. All underwent a detailed assessment, including VPT measurement. Cohort 2 also had liver ultrasound and transient elastography (TE). NAFLD Fibrosis Score (NFS) was calculated for all with available data. Follow-up VPT measurements on participants in Cohort 1 to 2014 were also collected if available.RESULTS: Adjusted risk of higher VPT category (≥25V but <50V, or ≥50V, c.f. < 25V) was greater for high-risk NFS in both cohorts (Cohort 1, OR 2.22 [95% CI 1.24-3.98, p=0.007] and Cohort 2, OR 4.51 [95% CI 1.08-18.87], p=0.039) and higher liver stiffness measurement (LSM) by TE in Cohort 2 (OR for each unit natural log increase in LSM of 2.42 (95% CI 1.13-5.19), p=0.023). In Cohort 1, in those with VPT<50V and complete data, those with higher NFS had greater odds of increasing VPT category after 2.2 (IQR 1.5-2.9) years.CONCLUSIONS: Higher VPT associates with markers of liver fibrosis due to NAFLD in diabetes mellitus.
AB - AIM: To examine for an association of elevated lower-limb vibration perception threshold (VPT) with NAFLD fibrosis.METHODS: Two cohorts from a tertiary diabetes centre were studied - Cohort 1, n=456 with type 1 or 2 diabetes, and Cohort 2, n=106 with type 2 diabetes mellitus. All underwent a detailed assessment, including VPT measurement. Cohort 2 also had liver ultrasound and transient elastography (TE). NAFLD Fibrosis Score (NFS) was calculated for all with available data. Follow-up VPT measurements on participants in Cohort 1 to 2014 were also collected if available.RESULTS: Adjusted risk of higher VPT category (≥25V but <50V, or ≥50V, c.f. < 25V) was greater for high-risk NFS in both cohorts (Cohort 1, OR 2.22 [95% CI 1.24-3.98, p=0.007] and Cohort 2, OR 4.51 [95% CI 1.08-18.87], p=0.039) and higher liver stiffness measurement (LSM) by TE in Cohort 2 (OR for each unit natural log increase in LSM of 2.42 (95% CI 1.13-5.19), p=0.023). In Cohort 1, in those with VPT<50V and complete data, those with higher NFS had greater odds of increasing VPT category after 2.2 (IQR 1.5-2.9) years.CONCLUSIONS: Higher VPT associates with markers of liver fibrosis due to NAFLD in diabetes mellitus.
KW - Aged
KW - Biomarkers
KW - Cohort Studies
KW - Diabetes Mellitus, Type 1/complications
KW - Diabetes Mellitus, Type 2/complications
KW - Diabetic Neuropathies/complications
KW - Elasticity Imaging Techniques
KW - Female
KW - Follow-Up Studies
KW - Foot
KW - Humans
KW - Liver/diagnostic imaging
KW - Liver Cirrhosis/etiology
KW - Male
KW - Middle Aged
KW - New South Wales/epidemiology
KW - Non-alcoholic Fatty Liver Disease/complications
KW - Peripheral Nerves/physiopathology
KW - Risk Factors
KW - Sensory Thresholds
KW - Severity of Illness Index
KW - Vibration
UR - https://www.scopus.com/pages/publications/84948712883
U2 - 10.1016/j.jdiacomp.2015.06.015
DO - 10.1016/j.jdiacomp.2015.06.015
M3 - Article
C2 - 26297218
SN - 1056-8727
VL - 29
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
IS - 8
ER -
