An Air-Stable Nickel(0) Phosphite Precatalyst for Primary Alkylamine C-N Cross-Coupling Reactions

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26 Citations (Scopus)

Abstract

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. In this report we describe the design and preparation of a new air-stable nickel phosphite based catalyst for unique C-N bond forming processes. Specifically, (BINAP)Ni[P(OPh)3]2, is presented as an effective catalyst for a range of amination reactions between aryl halides and primary alkylamines. The results are supported by relevant kinetic studies, DFT calculations and a catalytic cycle indicating possible reaction intermediates. The amination reaction between a series of aryl halides and primary alkylamines is described using a new air-stable nickel phosphite based catalyst (BINAP)Ni[P(OPh)3]2.
Original languageEnglish
Pages (from-to)5995-6004
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number27
DOIs
Publication statusPublished - 2015

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