Amyloid burden and incident depressive symptoms in cognitively normal older adults

for the AIBL Research Group

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period. Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18-month intervals over 54 months. Results: Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54-month assessment. Conclusions: Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ.

Original languageEnglish
Pages (from-to)455-463
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017
Externally publishedYes

Fingerprint

Amyloid
Depression
Alzheimer Disease
Neuroimaging
Geriatrics
Positron-Emission Tomography
Cerebrospinal Fluid
Life Style
Biomarkers
Observation
Confidence Intervals
Incidence

Cite this

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title = "Amyloid burden and incident depressive symptoms in cognitively normal older adults",
abstract = "Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period. Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18-month intervals over 54 months. Results: Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95{\%} confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9{\%}) than the low Aβ group (2{\%}) by the 54-month assessment. Conclusions: Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ.",
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author = "{for the AIBL Research Group} and Harrington, {Karra D.} and Emma Gould and Lim, {Yen Ying} and David Ames and Pietrzak, {Robert H.} and Alan Rembach and Stephanie Rainey-Smith and Martins, {Ralph N.} and Olivier Salvado and Villemagne, {Victor L.} and Rowe, {Christopher C.} and Masters, {Colin L.} and Paul Maruff",
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Amyloid burden and incident depressive symptoms in cognitively normal older adults. / for the AIBL Research Group.

In: International Journal of Geriatric Psychiatry, Vol. 32, No. 4, 01.04.2017, p. 455-463.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Amyloid burden and incident depressive symptoms in cognitively normal older adults

AU - for the AIBL Research Group

AU - Harrington, Karra D.

AU - Gould, Emma

AU - Lim, Yen Ying

AU - Ames, David

AU - Pietrzak, Robert H.

AU - Rembach, Alan

AU - Rainey-Smith, Stephanie

AU - Martins, Ralph N.

AU - Salvado, Olivier

AU - Villemagne, Victor L.

AU - Rowe, Christopher C.

AU - Masters, Colin L.

AU - Maruff, Paul

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period. Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18-month intervals over 54 months. Results: Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54-month assessment. Conclusions: Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ.

AB - Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period. Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18-month intervals over 54 months. Results: Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54-month assessment. Conclusions: Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ.

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SN - 0885-6230

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