Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.
|Journal||Medical Journal of Australia|
|Publication status||Published - 2006|
Isbister, G. K., Murray, L., John, S., Hackett, L. P., Haider, T., O'Mullane, P., Gosselin, S., & Daly, F. (2006). Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes. Medical Journal of Australia, 184(7), 354-356.