Ameliorating fibrosis at the DNA and the Protein level.

Priyanka Toshniwal

doi:10.26182/5e321fe208bb2

Ameliorating fibrosis at the DNA and the Protein level.

Priyanka Toshniwal

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Despite the significant consequences of fibrotic diseases there remains no widely effective therapeutic approach. This thesis aimed to investigate changes in the genome and proteome that maybe targeted to treat fibrosis. A role for DNA G-quadruplexes and Lysyl oxidase (LOX) enzyme activity in regulating extracellular matrix deposition was investigated. In addition, RNASeq and metabolic tracing were used to better understand the dynamic changes in gene and protein expression linked to fibrosis. The study provided significant new insight in o the biology of fibrosis and evidence to support novel therapeutic approaches, for example the potential to target quadruplex formation, for treating fibrosis.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Smith, Nicole, Supervisor Swaminatha Iyer, Killugudi, Supervisor Fear, Mark, Supervisor Wood, Fiona, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	7 Nov 2019
DOIs	https://doi.org/10.26182/5e321fe208bb2
Publication status	Unpublished - 2019

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TH20 6 THESIS - DOCTOR OF PHILOSOPHY - TOSHNIWAL Priyanka - 2019
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Cite this

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title = "Ameliorating fibrosis at the DNA and the Protein level.",

abstract = "Despite the significant consequences of fibrotic diseases there remains no widely effective therapeutic approach. This thesis aimed to investigate changes in the genome and proteome that maybe targeted to treat fibrosis. A role for DNA G-quadruplexes and Lysyl oxidase (LOX) enzyme activity in regulating extracellular matrix deposition was investigated. In addition, RNASeq and metabolic tracing were used to better understand the dynamic changes in gene and protein expression linked to fibrosis. The study provided significant new insight in o the biology of fibrosis and evidence to support novel therapeutic approaches, for example the potential to target quadruplex formation, for treating fibrosis. ",

keywords = "Fibrosis, Collagen, Extracellular matrix, G-quadruplexes, Epigenetics, Transcriptomics, Collagen turnover, Dupuytren's disease",

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language = "English",

school = "The University of Western Australia",

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AB - Despite the significant consequences of fibrotic diseases there remains no widely effective therapeutic approach. This thesis aimed to investigate changes in the genome and proteome that maybe targeted to treat fibrosis. A role for DNA G-quadruplexes and Lysyl oxidase (LOX) enzyme activity in regulating extracellular matrix deposition was investigated. In addition, RNASeq and metabolic tracing were used to better understand the dynamic changes in gene and protein expression linked to fibrosis. The study provided significant new insight in o the biology of fibrosis and evidence to support novel therapeutic approaches, for example the potential to target quadruplex formation, for treating fibrosis.

KW - Fibrosis

KW - Collagen

KW - Extracellular matrix

KW - G-quadruplexes

KW - Epigenetics

KW - Transcriptomics

KW - Collagen turnover

KW - Dupuytren's disease

U2 - 10.26182/5e321fe208bb2

DO - 10.26182/5e321fe208bb2

M3 - Doctoral Thesis

ER -

Ameliorating fibrosis at the DNA and the Protein level.

Abstract

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