Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series

V.A. Fabian, T.M. Jones, Steve Wilton, J.E. Dench, M.R. Davis, L. Lim, Byron Kakulas

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To determine the relationship between the apolipoprotein E epsilon 4 allele and autopsy-verified Alzheimer's disease (AD) in an Australian population.Design: Retrospective case-control study.Setting: Royal Perth Hospital, Perth, Western Australia (a tertiary referral hospital).Subjects: 50 subjects with ''definite'' AD (according to the histological and clinical criteria of the Consortium to Establish a Registry for Alzheimer's Disease [CERAD]) and 30 control subjects who had died from a non-neurological disease were randomly selected from the hospital's neuropathology register.Outcome measures: Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE).Results: Frequency of the epsilon 4 allele was significantly higher in the AD group (37%) than in the control group (2%) (chi(2)=25.8; P
Original languageEnglish
Pages (from-to)77-80
JournalMedical Journal of Australia
Volume165
Issue number15 July
Publication statusPublished - 1996

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