Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

Siobhan Brennan; Peter Sly; Catherine Gangell; N. Sturges; K. Winfield; Matthew Wikstrom; S. Gard; John Upham; [No Value] Arest Cf Group

doi:10.1183/09031936.00178508

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

Siobhan Brennan
, Peter Sly
, Catherine Gangell
, N. Sturges
, K. Winfield
, Matthew Wikstrom
, S. Gard
, John Upham
, [No Value] Arest Cf Group

Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)
UWA Centre for Child Health Research (affiliated with the The Kids Research Institute Australia)

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms.Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223×103 versus 85×103 cells·mL−1; p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3α (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg·mL−1; p

Original language	English
Pages (from-to)	655-661
Journal	European Respiratory Journal
Volume	34
Issue number	3
DOIs	https://doi.org/10.1183/09031936.00178508
Publication status	Published - 2009

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1183/09031936.00178508

Cite this

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title = "Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis",

abstract = "Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms.Pulmonary infection was detected in 31\% (16 out of 51) and 38\% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223×103 versus 85×103 cells·mL−1; p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3α (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg·mL−1; p",

author = "Siobhan Brennan and Peter Sly and Catherine Gangell and N. Sturges and K. Winfield and Matthew Wikstrom and S. Gard and John Upham and \{Arest Cf Group\}, \{[No Value]\}",

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T1 - Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

AU - Brennan, Siobhan

AU - Sly, Peter

AU - Gangell, Catherine

AU - Sturges, N.

AU - Winfield, K.

AU - Wikstrom, Matthew

AU - Gard, S.

AU - Upham, John

AU - Arest Cf Group, [No Value]

PY - 2009

Y1 - 2009

N2 - Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms.Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223×103 versus 85×103 cells·mL−1; p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3α (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg·mL−1; p

AB - Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms.Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223×103 versus 85×103 cells·mL−1; p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3α (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg·mL−1; p

U2 - 10.1183/09031936.00178508

DO - 10.1183/09031936.00178508

M3 - Article

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SN - 0903-1936

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SP - 655

EP - 661

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 3

ER -

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

Abstract

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