TY - JOUR
T1 - AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population
AU - Hui, J.
AU - Palmer, L.J.
AU - James, A.L.
AU - Musk, A.W.
AU - Beilby, John
PY - 2006
Y1 - 2006
N2 - Aim To examine the association between the Alu dimorphism within the first intron of the MICB gene and asthma and airflow obstruction.Background The highly polymorphic non-classical MHC class I polypeptide-related (MIC) genes, MICA and MICB, encode stress inducible glycoproteins, which are expressed on a variety of epithelial cells, including those of the lungs.Methods AluyMICB genotyping was performed on 1109 subjects from the Busselton Health Study. From a standard questionnaire, 359 individuals indicated that they had been diagnosed by a doctor with asthma. Lung function was assessed by the forced expired volume in 1 second (FEV1) and expressed as a percent of the predicted value. Airflow obstruction was defined as FEV1
AB - Aim To examine the association between the Alu dimorphism within the first intron of the MICB gene and asthma and airflow obstruction.Background The highly polymorphic non-classical MHC class I polypeptide-related (MIC) genes, MICA and MICB, encode stress inducible glycoproteins, which are expressed on a variety of epithelial cells, including those of the lungs.Methods AluyMICB genotyping was performed on 1109 subjects from the Busselton Health Study. From a standard questionnaire, 359 individuals indicated that they had been diagnosed by a doctor with asthma. Lung function was assessed by the forced expired volume in 1 second (FEV1) and expressed as a percent of the predicted value. Airflow obstruction was defined as FEV1
U2 - 10.1111/j.1365-2222.2006.02495.x
DO - 10.1111/j.1365-2222.2006.02495.x
M3 - Article
C2 - 16776673
SN - 0954-7894
VL - 36
SP - 728
EP - 734
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
IS - 6
ER -
