Alu polymorphism within the MICB gene and association with HLA-B alleles

Jerzy K. Kulski; David S. Dunn; Jennie Hui; Patricia Martinez; Amornrat V. Romphruk; Chanvit Leelayuwat; Guan K. Tay; Akira Oka; Hidetoshi Inoko

doi:10.1007/s00251-001-0409-5

Alu polymorphism within the MICB gene and association with HLA-B alleles

Jerzy K. Kulski, David S. Dunn, Jennie Hui, Patricia Martinez, Amornrat V. Romphruk, Chanvit Leelayuwat, Guan K. Tay, Akira Oka, Hidetoshi Inoko

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24 Citations (Scopus)

Abstract

We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.

Original language	English
Pages (from-to)	975-979
Number of pages	5
Journal	Immunogenetics
Volume	53
Issue number	10-11
DOIs	https://doi.org/10.1007/s00251-001-0409-5
Publication status	Published - 2002

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@article{28b76d498e90421a98f57901e3174752,

title = "Alu polymorphism within the MICB gene and association with HLA-B alleles",

abstract = "We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.",

keywords = "Alu, Haplotypes, HLA, MHC, MICB",

author = "Kulski, {Jerzy K.} and Dunn, {David S.} and Jennie Hui and Patricia Martinez and Romphruk, {Amornrat V.} and Chanvit Leelayuwat and Tay, {Guan K.} and Akira Oka and Hidetoshi Inoko",

note = "Funding Information: Acknowledgements We thank Campbell Witt and Frank Christiansen for access to cell lines, caucasoid samples, and HLA data. The study was partly funded by NHMRC. The AluyMICB polymorphism has been submitted to HGBASE with the accession number IND000574338.",

year = "2002",

doi = "10.1007/s00251-001-0409-5",

language = "English",

volume = "53",

pages = "975--979",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer-Verlag London Ltd.",

number = "10-11",

}

TY - JOUR

T1 - Alu polymorphism within the MICB gene and association with HLA-B alleles

AU - Kulski, Jerzy K.

AU - Dunn, David S.

AU - Hui, Jennie

AU - Martinez, Patricia

AU - Romphruk, Amornrat V.

AU - Leelayuwat, Chanvit

AU - Tay, Guan K.

AU - Oka, Akira

AU - Inoko, Hidetoshi

N1 - Funding Information: Acknowledgements We thank Campbell Witt and Frank Christiansen for access to cell lines, caucasoid samples, and HLA data. The study was partly funded by NHMRC. The AluyMICB polymorphism has been submitted to HGBASE with the accession number IND000574338.

PY - 2002

Y1 - 2002

N2 - We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.

AB - We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.

KW - Alu

KW - Haplotypes

KW - HLA

KW - MHC

KW - MICB

UR - http://www.scopus.com/inward/record.url?scp=0036196005&partnerID=8YFLogxK

U2 - 10.1007/s00251-001-0409-5

DO - 10.1007/s00251-001-0409-5

M3 - Article

C2 - 11862397

AN - SCOPUS:0036196005

SN - 0093-7711

VL - 53

SP - 975

EP - 979

JO - Immunogenetics

JF - Immunogenetics

IS - 10-11

ER -

Alu polymorphism within the MICB gene and association with HLA-B alleles

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