Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Anderson P Jones; Stephanie Trend; Scott N Byrne; Marzena J Fabis-Pedrini; Sian Geldenhuys; David Nolan; David R Booth; William M Carroll; Robyn M Lucas; Allan G Kermode; Prue H Hart

doi:10.1038/cti.2017.18

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Anderson P Jones, Stephanie Trend, Scott N Byrne, Marzena J Fabis-Pedrini, Sian Geldenhuys, David Nolan, David R Booth, William M Carroll, Robyn M Lucas, Allan G Kermode, Prue H Hart

Research output: Contribution to journal › Article › peer-review

19 Citations (Web of Science)

Abstract

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (

Original language	English
Article number	e143
Journal	Clinical & Translational Immunology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/cti.2017.18
Publication status	Published - May 2017

Access to Document

10.1038/cti.2017.18Licence: CC BY

Cite this

Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G., & Hart, P. H. (2017). Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis. Clinical & Translational Immunology, 6(5), [e143]. https://doi.org/10.1038/cti.2017.18

Jones, Anderson P ; Trend, Stephanie ; Byrne, Scott N ; Fabis-Pedrini, Marzena J ; Geldenhuys, Sian ; Nolan, David ; Booth, David R ; Carroll, William M ; Lucas, Robyn M ; Kermode, Allan G ; Hart, Prue H. / Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome : clues to the development of multiple sclerosis. In: Clinical & Translational Immunology. 2017 ; Vol. 6, No. 5.

@article{725ef4ca14934e0faaf8dd2091f0851f,

title = "Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis",

abstract = "Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (",

author = "Jones, {Anderson P} and Stephanie Trend and Byrne, {Scott N} and Fabis-Pedrini, {Marzena J} and Sian Geldenhuys and David Nolan and Booth, {David R} and Carroll, {William M} and Lucas, {Robyn M} and Kermode, {Allan G} and Hart, {Prue H}",

year = "2017",

month = may,

doi = "10.1038/cti.2017.18",

language = "English",

volume = "6",

journal = "Clinical & Translational Immunology",

issn = "2050-0068",

publisher = "John Wiley & Sons",

number = "5",

}

Jones, AP, Trend, S, Byrne, SN, Fabis-Pedrini, MJ, Geldenhuys, S, Nolan, D, Booth, DR, Carroll, WM, Lucas, RM, Kermode, AG & Hart, PH 2017, 'Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis', Clinical & Translational Immunology, vol. 6, no. 5, e143. https://doi.org/10.1038/cti.2017.18

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome : clues to the development of multiple sclerosis. / Jones, Anderson P; Trend, Stephanie; Byrne, Scott N; Fabis-Pedrini, Marzena J; Geldenhuys, Sian; Nolan, David; Booth, David R; Carroll, William M; Lucas, Robyn M; Kermode, Allan G ; Hart, Prue H.

In: Clinical & Translational Immunology, Vol. 6, No. 5, e143, 05.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome

T2 - clues to the development of multiple sclerosis

AU - Jones, Anderson P

AU - Trend, Stephanie

AU - Byrne, Scott N

AU - Fabis-Pedrini, Marzena J

AU - Geldenhuys, Sian

AU - Nolan, David

AU - Booth, David R

AU - Carroll, William M

AU - Lucas, Robyn M

AU - Kermode, Allan G

AU - Hart, Prue H

PY - 2017/5

Y1 - 2017/5

N2 - Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (

AB - Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (

U2 - 10.1038/cti.2017.18

DO - 10.1038/cti.2017.18

M3 - Article

C2 - 28690849

VL - 6

JO - Clinical & Translational Immunology

JF - Clinical & Translational Immunology

SN - 2050-0068

IS - 5

M1 - e143

ER -

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Abstract

Access to Document

Fingerprint

Cite this