Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Anderson P Jones; Stephanie Trend; Scott N Byrne; Marzena J Fabis-Pedrini; Sian Geldenhuys; David Nolan; David R Booth; William M Carroll; Robyn M Lucas; Allan G Kermode; Prue H Hart

doi:10.1038/cti.2017.18

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Anderson P Jones, Stephanie Trend, Scott N Byrne, Marzena J Fabis-Pedrini, Sian Geldenhuys, David Nolan, David R Booth, William M Carroll, Robyn M Lucas, Allan G Kermode, Prue H Hart

Research output: Contribution to journal › Article

Abstract

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (

Original language	English
Article number	e143
Journal	Clinical & Translational Immunology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/cti.2017.18
Publication status	Published - May 2017

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Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G., & Hart, P. H. (2017). Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis. Clinical & Translational Immunology, 6(5), [e143]. https://doi.org/10.1038/cti.2017.18

Jones, Anderson P ; Trend, Stephanie ; Byrne, Scott N ; Fabis-Pedrini, Marzena J ; Geldenhuys, Sian ; Nolan, David ; Booth, David R ; Carroll, William M ; Lucas, Robyn M ; Kermode, Allan G ; Hart, Prue H. / Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome : clues to the development of multiple sclerosis. In: Clinical & Translational Immunology. 2017 ; Vol. 6, No. 5.

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abstract = "Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells fromn=18 treatment-naive individuals with recently diagnosed CIS (",

author = "Jones, {Anderson P} and Stephanie Trend and Byrne, {Scott N} and Fabis-Pedrini, {Marzena J} and Sian Geldenhuys and David Nolan and Booth, {David R} and Carroll, {William M} and Lucas, {Robyn M} and Kermode, {Allan G} and Hart, {Prue H}",

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Jones, AP, Trend, S, Byrne, SN, Fabis-Pedrini, MJ, Geldenhuys, S, Nolan, D, Booth, DR, Carroll, WM, Lucas, RM, Kermode, AG & Hart, PH 2017, 'Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis', Clinical & Translational Immunology, vol. 6, no. 5, e143. https://doi.org/10.1038/cti.2017.18

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome : clues to the development of multiple sclerosis. / Jones, Anderson P; Trend, Stephanie; Byrne, Scott N; Fabis-Pedrini, Marzena J; Geldenhuys, Sian; Nolan, David; Booth, David R; Carroll, William M; Lucas, Robyn M; Kermode, Allan G ; Hart, Prue H.

In: Clinical & Translational Immunology, Vol. 6, No. 5, e143, 05.2017.

Research output: Contribution to journal › Article

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AU - Fabis-Pedrini, Marzena J

AU - Geldenhuys, Sian

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AU - Booth, David R

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AU - Hart, Prue H

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