Alpha-1-antitrypsin variation in Southern Africa

D. S. Dunn, B. Madhoo, R. Turnbull, Trefor Jenkins

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Eleven Southern African populations were shown to be polymorphic at the α1-antitrypsin locus. A 'new' electrophoretically detectable α1-antitrypsin variant (PiWsan) which has a lower isoelectric point than does PiM, was found in the Bantu-speaking Negro and San populations. PiWsan appears to be functionally normal as judged by quantitative and qualitative studies.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalHuman Heredity
Issue number4
Publication statusPublished - 1986
Externally publishedYes


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