Alpha-1-antitrypsin variation in Southern Africa

D. S. Dunn; B. Madhoo; R. Turnbull; Trefor Jenkins

doi:10.1159/000153633

Alpha-1-antitrypsin variation in Southern Africa

D. S. Dunn, B. Madhoo, R. Turnbull, Trefor Jenkins

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Eleven Southern African populations were shown to be polymorphic at the α₁-antitrypsin locus. A 'new' electrophoretically detectable α₁-antitrypsin variant (Pi^Wsan) which has a lower isoelectric point than does Pi^M, was found in the Bantu-speaking Negro and San populations. Pi^Wsan appears to be functionally normal as judged by quantitative and qualitative studies.

Original language	English
Pages (from-to)	238-242
Number of pages	5
Journal	Human Heredity
Volume	36
Issue number	4
DOIs	https://doi.org/10.1159/000153633
Publication status	Published - 1986
Externally published	Yes

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title = "Alpha-1-antitrypsin variation in Southern Africa",

abstract = "Eleven Southern African populations were shown to be polymorphic at the α1-antitrypsin locus. A 'new' electrophoretically detectable α1-antitrypsin variant (PiWsan) which has a lower isoelectric point than does PiM, was found in the Bantu-speaking Negro and San populations. PiWsan appears to be functionally normal as judged by quantitative and qualitative studies.",

author = "Dunn, {D. S.} and B. Madhoo and R. Turnbull and Trefor Jenkins",

year = "1986",

doi = "10.1159/000153633",

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pages = "238--242",

journal = "Human Heredity",

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T1 - Alpha-1-antitrypsin variation in Southern Africa

AU - Dunn, D. S.

AU - Madhoo, B.

AU - Turnbull, R.

AU - Jenkins, Trefor

PY - 1986

Y1 - 1986

N2 - Eleven Southern African populations were shown to be polymorphic at the α1-antitrypsin locus. A 'new' electrophoretically detectable α1-antitrypsin variant (PiWsan) which has a lower isoelectric point than does PiM, was found in the Bantu-speaking Negro and San populations. PiWsan appears to be functionally normal as judged by quantitative and qualitative studies.

AB - Eleven Southern African populations were shown to be polymorphic at the α1-antitrypsin locus. A 'new' electrophoretically detectable α1-antitrypsin variant (PiWsan) which has a lower isoelectric point than does PiM, was found in the Bantu-speaking Negro and San populations. PiWsan appears to be functionally normal as judged by quantitative and qualitative studies.

UR - http://www.scopus.com/inward/record.url?scp=0022549951&partnerID=8YFLogxK

U2 - 10.1159/000153633

DO - 10.1159/000153633

M3 - Article

C2 - 3489664

AN - SCOPUS:0022549951

SN - 0001-5652

VL - 36

SP - 238

EP - 242

JO - Human Heredity

JF - Human Heredity

IS - 4

ER -

Alpha-1-antitrypsin variation in Southern Africa

Abstract

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