Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)

Jasmine B. Taylor, Tarrant D R Cummins, Allison M. Fox, Beth P. Johnson, Janette H. Tong, Troy A W Visser, Ziarih Hawi, Mark A. Bellgrove

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalThe World Journal of Biological Psychiatry
Volume19
Issue numbersup2
Early online date20 Jan 2017
DOIs
Publication statusPublished - 2018

Fingerprint

Dopamine D2 Receptors
Genes
Catecholamines
Impulsive Behavior
Individuality
Single Nucleotide Polymorphism
Alleles
DNA

Cite this

Taylor, Jasmine B. ; Cummins, Tarrant D R ; Fox, Allison M. ; Johnson, Beth P. ; Tong, Janette H. ; Visser, Troy A W ; Hawi, Ziarih ; Bellgrove, Mark A. / Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11). In: The World Journal of Biological Psychiatry. 2018 ; Vol. 19, No. sup2. pp. 1-9.
@article{19ee347855514580b6d8e34e803b058e,
title = "Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)",
abstract = "Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.",
keywords = "attention, BIS, catecholamine, DRD2, impulsivity",
author = "Taylor, {Jasmine B.} and Cummins, {Tarrant D R} and Fox, {Allison M.} and Johnson, {Beth P.} and Tong, {Janette H.} and Visser, {Troy A W} and Ziarih Hawi and Bellgrove, {Mark A.}",
year = "2018",
doi = "10.1080/15622975.2016.1273549",
language = "English",
volume = "19",
pages = "1--9",
journal = "The World Journal of Biological Psychiatry",
issn = "1562-2975",
publisher = "Informa Healthcare USA",
number = "sup2",

}

Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11). / Taylor, Jasmine B.; Cummins, Tarrant D R; Fox, Allison M.; Johnson, Beth P.; Tong, Janette H.; Visser, Troy A W; Hawi, Ziarih; Bellgrove, Mark A.

In: The World Journal of Biological Psychiatry, Vol. 19, No. sup2, 2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)

AU - Taylor, Jasmine B.

AU - Cummins, Tarrant D R

AU - Fox, Allison M.

AU - Johnson, Beth P.

AU - Tong, Janette H.

AU - Visser, Troy A W

AU - Hawi, Ziarih

AU - Bellgrove, Mark A.

PY - 2018

Y1 - 2018

N2 - Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

AB - Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

KW - attention

KW - BIS

KW - catecholamine

KW - DRD2

KW - impulsivity

UR - http://www.scopus.com/inward/record.url?scp=85009951485&partnerID=8YFLogxK

U2 - 10.1080/15622975.2016.1273549

DO - 10.1080/15622975.2016.1273549

M3 - Article

VL - 19

SP - 1

EP - 9

JO - The World Journal of Biological Psychiatry

JF - The World Journal of Biological Psychiatry

SN - 1562-2975

IS - sup2

ER -