Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Bjorn Bohman; B.W. Berntsson; R.C.M. Dixon; C.D. Stewart; R.A. Barrow

doi:10.1021/ol500776j

Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Bjorn Bohman, B.W. Berntsson, R.C.M. Dixon, C.D. Stewart, R.A. Barrow

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones. © 2014 American Chemical Society.

Original language	English
Pages (from-to)	2787-2789
Number of pages	3
Journal	Organic Letters
Volume	16
Issue number	11
Early online date	13 May 2014
DOIs	https://doi.org/10.1021/ol500776j
Publication status	Published - 6 Jun 2014

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title = "Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions",

abstract = "A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones. {\textcopyright} 2014 American Chemical Society.",

author = "Bjorn Bohman and B.W. Berntsson and R.C.M. Dixon and C.D. Stewart and R.A. Barrow",

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AU - Bohman, Bjorn

AU - Berntsson, B.W.

AU - Dixon, R.C.M.

AU - Stewart, C.D.

AU - Barrow, R.A.

PY - 2014/6/6

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N2 - A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones. © 2014 American Chemical Society.

AB - A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones. © 2014 American Chemical Society.

U2 - 10.1021/ol500776j

DO - 10.1021/ol500776j

M3 - Article

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EP - 2789

JO - Organic Letters

JF - Organic Letters

SN - 1523-7052

IS - 11

ER -

Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Abstract

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