Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Bjorn Bohman, B.W. Berntsson, R.C.M. Dixon, C.D. Stewart, R.A. Barrow

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones. © 2014 American Chemical Society.
Original languageEnglish
Pages (from-to)2787-2789
Number of pages3
JournalOrganic Letters
Issue number11
Early online date13 May 2014
Publication statusPublished - 6 Jun 2014


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