Alexidine dihydrochloride and Thonzonium bromide: Novel Modulators of Osteoclast Formation & Function

Excessive bone resorption by osteoclasts is the main pathological cause of many osteolytic bone diseases including osteoporosis. In this thesis, Xiang Zhu identified two agents commonly used in dental applications, Alexidine dihydrochloride and Thonzonium bromide, as novel modulators of osteoclast formation and bone resorption in vitro. Both agents exert its inhibitory effect via the suppression of RAN KL-induced signalling pathways crucial for osteoclast formation and effective bone resorption. Additionally, these agents demonstrated potential therapeutic applications by preventing bone loss associated with infection and inflammation.