Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Nicholas G Larkins, Siah Kim, John B Carlin, Anneke C Grobler, David P Burgner, Katherine Lange, Jonathan C Craig, Melissa Wake

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: To describe the distribution of albuminuria among Australian children aged 11-12 years and their parents, and assess its intergenerational concordance within parent-child dyads.

DESIGN: Population-based cross-sectional study (the Child Health CheckPoint), nested within the Longitudinal Study of Australian Children.

SETTING: Assessment centres (seven Australian cities and eight regional towns) and home visits across Australia, February 2015 to March 2016.

PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1557 children (46.2% girls) and 1454 parents (85.5% mothers) provided random urine samples at the visit; samples from menstruating females were excluded.

OUTCOME MEASURES: Urine albumin-to-creatinine ratio (ACR) and its components (urine albumin and creatinine concentration); albuminuria was defined as an ACR ≥3.4 mg/mmol. Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance, using log-transformed data due to skewing. Survey weights and methods were applied to account for the complex sample design.

RESULTS: The median ACR for children was 1.03 mg/mmol (IQR 0.65-1.97) and 1.01 mg/mmol (IQR 0.60-2.09) for adults. The median ACR was higher in girls (1.20, IQR 0.71-2.65) than boys (0.90, IQR 0.61-1.65) and in mothers (1.13, IQR 0.63-2.33) than fathers (0.66, IQR 0.41-1.05). Albuminuria was detected in 15.1% of children (girls 20.8%, boys 10.1%) and 13.5% of adults (15.1% mothers, 4.0% fathers) had albuminuria. There was a small correlation between parent and child ACR (Pearson correlation coefficient 0.06, 95% CI 0.01 to 0.12).

CONCLUSIONS: Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease, and mortality. The weak concordance among intergenerational pairs for urine ACR suggests either that genetic heritability is low or that it becomes evident only at later offspring life stages.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalBMJ Open
Volume9
Issue numberSuppl 3
DOIs
Publication statusPublished - 4 Jul 2019
Externally publishedYes

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Albuminuria
Epidemiology
Parents
Albumins
Creatinine
Population
Urine
Mothers
Fathers
Linear Models
House Calls
Kidney Diseases
Longitudinal Studies
Cardiovascular Diseases
Cross-Sectional Studies
Weights and Measures
Mortality

Cite this

Larkins, Nicholas G ; Kim, Siah ; Carlin, John B ; Grobler, Anneke C ; Burgner, David P ; Lange, Katherine ; Craig, Jonathan C ; Wake, Melissa. / Albuminuria : population epidemiology and concordance in Australian children aged 11-12 years and their parents. In: BMJ Open. 2019 ; Vol. 9, No. Suppl 3. pp. 75-84.
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title = "Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents",
abstract = "OBJECTIVES: To describe the distribution of albuminuria among Australian children aged 11-12 years and their parents, and assess its intergenerational concordance within parent-child dyads.DESIGN: Population-based cross-sectional study (the Child Health CheckPoint), nested within the Longitudinal Study of Australian Children.SETTING: Assessment centres (seven Australian cities and eight regional towns) and home visits across Australia, February 2015 to March 2016.PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1557 children (46.2{\%} girls) and 1454 parents (85.5{\%} mothers) provided random urine samples at the visit; samples from menstruating females were excluded.OUTCOME MEASURES: Urine albumin-to-creatinine ratio (ACR) and its components (urine albumin and creatinine concentration); albuminuria was defined as an ACR ≥3.4 mg/mmol. Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance, using log-transformed data due to skewing. Survey weights and methods were applied to account for the complex sample design.RESULTS: The median ACR for children was 1.03 mg/mmol (IQR 0.65-1.97) and 1.01 mg/mmol (IQR 0.60-2.09) for adults. The median ACR was higher in girls (1.20, IQR 0.71-2.65) than boys (0.90, IQR 0.61-1.65) and in mothers (1.13, IQR 0.63-2.33) than fathers (0.66, IQR 0.41-1.05). Albuminuria was detected in 15.1{\%} of children (girls 20.8{\%}, boys 10.1{\%}) and 13.5{\%} of adults (15.1{\%} mothers, 4.0{\%} fathers) had albuminuria. There was a small correlation between parent and child ACR (Pearson correlation coefficient 0.06, 95{\%} CI 0.01 to 0.12).CONCLUSIONS: Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease, and mortality. The weak concordance among intergenerational pairs for urine ACR suggests either that genetic heritability is low or that it becomes evident only at later offspring life stages.",
author = "Larkins, {Nicholas G} and Siah Kim and Carlin, {John B} and Grobler, {Anneke C} and Burgner, {David P} and Katherine Lange and Craig, {Jonathan C} and Melissa Wake",
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Larkins, NG, Kim, S, Carlin, JB, Grobler, AC, Burgner, DP, Lange, K, Craig, JC & Wake, M 2019, 'Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents' BMJ Open, vol. 9, no. Suppl 3, pp. 75-84. https://doi.org/10.1136/bmjopen-2017-020262

Albuminuria : population epidemiology and concordance in Australian children aged 11-12 years and their parents. / Larkins, Nicholas G; Kim, Siah; Carlin, John B; Grobler, Anneke C; Burgner, David P; Lange, Katherine; Craig, Jonathan C; Wake, Melissa.

In: BMJ Open, Vol. 9, No. Suppl 3, 04.07.2019, p. 75-84.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Albuminuria

T2 - population epidemiology and concordance in Australian children aged 11-12 years and their parents

AU - Larkins, Nicholas G

AU - Kim, Siah

AU - Carlin, John B

AU - Grobler, Anneke C

AU - Burgner, David P

AU - Lange, Katherine

AU - Craig, Jonathan C

AU - Wake, Melissa

PY - 2019/7/4

Y1 - 2019/7/4

N2 - OBJECTIVES: To describe the distribution of albuminuria among Australian children aged 11-12 years and their parents, and assess its intergenerational concordance within parent-child dyads.DESIGN: Population-based cross-sectional study (the Child Health CheckPoint), nested within the Longitudinal Study of Australian Children.SETTING: Assessment centres (seven Australian cities and eight regional towns) and home visits across Australia, February 2015 to March 2016.PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1557 children (46.2% girls) and 1454 parents (85.5% mothers) provided random urine samples at the visit; samples from menstruating females were excluded.OUTCOME MEASURES: Urine albumin-to-creatinine ratio (ACR) and its components (urine albumin and creatinine concentration); albuminuria was defined as an ACR ≥3.4 mg/mmol. Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance, using log-transformed data due to skewing. Survey weights and methods were applied to account for the complex sample design.RESULTS: The median ACR for children was 1.03 mg/mmol (IQR 0.65-1.97) and 1.01 mg/mmol (IQR 0.60-2.09) for adults. The median ACR was higher in girls (1.20, IQR 0.71-2.65) than boys (0.90, IQR 0.61-1.65) and in mothers (1.13, IQR 0.63-2.33) than fathers (0.66, IQR 0.41-1.05). Albuminuria was detected in 15.1% of children (girls 20.8%, boys 10.1%) and 13.5% of adults (15.1% mothers, 4.0% fathers) had albuminuria. There was a small correlation between parent and child ACR (Pearson correlation coefficient 0.06, 95% CI 0.01 to 0.12).CONCLUSIONS: Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease, and mortality. The weak concordance among intergenerational pairs for urine ACR suggests either that genetic heritability is low or that it becomes evident only at later offspring life stages.

AB - OBJECTIVES: To describe the distribution of albuminuria among Australian children aged 11-12 years and their parents, and assess its intergenerational concordance within parent-child dyads.DESIGN: Population-based cross-sectional study (the Child Health CheckPoint), nested within the Longitudinal Study of Australian Children.SETTING: Assessment centres (seven Australian cities and eight regional towns) and home visits across Australia, February 2015 to March 2016.PARTICIPANTS: Of all participating CheckPoint families (n=1874), 1557 children (46.2% girls) and 1454 parents (85.5% mothers) provided random urine samples at the visit; samples from menstruating females were excluded.OUTCOME MEASURES: Urine albumin-to-creatinine ratio (ACR) and its components (urine albumin and creatinine concentration); albuminuria was defined as an ACR ≥3.4 mg/mmol. Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance, using log-transformed data due to skewing. Survey weights and methods were applied to account for the complex sample design.RESULTS: The median ACR for children was 1.03 mg/mmol (IQR 0.65-1.97) and 1.01 mg/mmol (IQR 0.60-2.09) for adults. The median ACR was higher in girls (1.20, IQR 0.71-2.65) than boys (0.90, IQR 0.61-1.65) and in mothers (1.13, IQR 0.63-2.33) than fathers (0.66, IQR 0.41-1.05). Albuminuria was detected in 15.1% of children (girls 20.8%, boys 10.1%) and 13.5% of adults (15.1% mothers, 4.0% fathers) had albuminuria. There was a small correlation between parent and child ACR (Pearson correlation coefficient 0.06, 95% CI 0.01 to 0.12).CONCLUSIONS: Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease, and mortality. The weak concordance among intergenerational pairs for urine ACR suggests either that genetic heritability is low or that it becomes evident only at later offspring life stages.

U2 - 10.1136/bmjopen-2017-020262

DO - 10.1136/bmjopen-2017-020262

M3 - Article

VL - 9

SP - 75

EP - 84

JO - BMJ (Open)

JF - BMJ (Open)

SN - 2044-6055

IS - Suppl 3

ER -