Albendazole: A more effective antigiardial agent in vitrothan metronidazole or tinidazole

B. P. Meloni; R. C.A. Thompson; J. A. Reynoldson; P. Seville

doi:10.1016/0035-9203(90)90324-8

Albendazole: A more effective antigiardial agent in vitrothan metronidazole or tinidazole

B. P. Meloni, R. C.A. Thompson, J. A. Reynoldson, P. Seville

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Abstract

The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis.

Original language	English
Pages (from-to)	375-379
Number of pages	5
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(90)90324-8
Publication status	Published - 1 Jun 1990
Externally published	Yes

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abstract = "The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis.",

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AU - Seville, P.

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AB - The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis.

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Albendazole: A more effective antigiardial agent in vitrothan metronidazole or tinidazole

Abstract

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