Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Samuele Sala, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, Gavin R. Flematti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

Original languageEnglish
Pages (from-to)3450-3455
Number of pages6
JournalJournal of Natural Products
Volume82
Issue number12
DOIs
Publication statusPublished - 27 Dec 2019

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