Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Samuele Sala, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, Gavin R. Flematti

Research output: Contribution to journalArticle

Abstract

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

Original languageEnglish
Pages (from-to)3450-3455
Number of pages6
JournalJournal of Natural Products
Volume82
Issue number12
DOIs
Publication statusPublished - 27 Dec 2019

Fingerprint

Bearings (structural)
Polyacetylenes
Giardia lamblia
Nitriles
Western Australia
Metronidazole
Porifera
Nuclear magnetic resonance spectroscopy
Mass spectrometry
Mass Spectrometry
Magnetic Resonance Spectroscopy
Infrared radiation

Cite this

Sala, Samuele ; Fromont, Jane ; Gomez, Oliver ; Vuong, Daniel ; Lacey, Ernest ; Flematti, Gavin R. / Albanitriles A-G : Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge. In: Journal of Natural Products. 2019 ; Vol. 82, No. 12. pp. 3450-3455.
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Albanitriles A-G : Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge. / Sala, Samuele; Fromont, Jane; Gomez, Oliver; Vuong, Daniel; Lacey, Ernest; Flematti, Gavin R.

In: Journal of Natural Products, Vol. 82, No. 12, 27.12.2019, p. 3450-3455.

Research output: Contribution to journalArticle

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