Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Samuele Sala; Jane Fromont; Oliver Gomez; Daniel Vuong; Ernest Lacey; Gavin R. Flematti

doi:10.1021/acs.jnatprod.9b00840

Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Samuele Sala, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, Gavin R. Flematti

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

Original language	English
Pages (from-to)	3450-3455
Number of pages	6
Journal	Journal of Natural Products
Volume	82
Issue number	12
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00840
Publication status	Published - 27 Dec 2019

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10.1021/acs.jnatprod.9b00840

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abstract = "Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.",

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AU - Sala, Samuele

AU - Fromont, Jane

AU - Gomez, Oliver

AU - Vuong, Daniel

AU - Lacey, Ernest

AU - Flematti, Gavin R.

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ER -

Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge

Abstract

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Chemical and biological investigations into the major secondary metabolites isolated from marine sponges of the Western Australian coast

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