Airway smooth muscle thickness in asthma is related to severity but not duration of asthma

Alan James, T.R. Bai, T. Mauad, M.J. Abramson, M. Dolnikoff, K.O. Mckay, P.S. Maxwell, J.G. Elliot, F.H. Green

    Research output: Contribution to journalArticle

    97 Citations (Scopus)

    Abstract

    Asthma is characterised by an increased airway smooth muscle (ASM) area (ASMarea) within the airway wall. The present study examined the relationship of factors including severity and duration of asthma to ASMarea.The perimeter of the basement membrane (PBM) and ASMarea were measured on transverse sections of large and small airways from post mortem cases of fatal (n = 107) and nonfatal asthma (n = 37) and from control subjects (n = 69). The thickness of ASM (ASMarea/PBM) was compared between asthma groups using multivariate linear regression.When all airways were considered together, ASMarea/PBM (in millimetres) was increased in nonfatal (median 0.04; interquartile range 0.013–0.051; p = 0.034) and fatal cases of asthma (0.048; 0.025–0.078; p
    Original languageEnglish
    Pages (from-to)1040-1045
    JournalEuropean Respiratory Journal
    Volume34
    Issue number5
    DOIs
    Publication statusPublished - 2009

    Fingerprint Dive into the research topics of 'Airway smooth muscle thickness in asthma is related to severity but not duration of asthma'. Together they form a unique fingerprint.

  • Cite this

    James, A., Bai, T. R., Mauad, T., Abramson, M. J., Dolnikoff, M., Mckay, K. O., ... Green, F. H. (2009). Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. European Respiratory Journal, 34(5), 1040-1045. https://doi.org/10.1183/09031936.00181608