Airway mechanics and methods used to visualize smooth muscle dynamics in vitro

P.R. Cooper, B.E. Mcparland, Howard Mitchell, Peter Noble, A.Z. Politi, A.R. Ressmeyer, Adrian West

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Contraction of airway smooth muscle (ASM) is regulated by the physiological, structural and mechanical environment in the lung. We review two in vitro techniques, lung slices and airway segment preparations, that enable in situ ASM contraction and airway narrowing to be visualized. Lung slices and airway segment approaches bridge a gap between cell culture and isolated ASM, and whole animal studies. Imaging techniques enable key upstream events involved in airway narrowing, such as ASM cell signalling and structural and mechanical events impinging on ASM, to be investigated.
Original languageEnglish
Pages (from-to)398-406
JournalPulmonary Pharmacology & Therapeutics
Volume22
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Airway mechanics and methods used to visualize smooth muscle dynamics in vitro'. Together they form a unique fingerprint.

Cite this