Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms

Donald Payne, Y. Qiu, J. Zhu, L. Peachey, M. Scallan, A. Bush, P.K. Jeffery

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Abstract

    The effective management and development of new treatments for children with difficult asthma requires investigation of the underlying airway pathology and its relationships with persistent symptoms and airflow limitation.Methods: The density of immunologically distinct inflammatory cells and cells expressing interleukin (IL)-4, IL-5, and RANTES was determined in paraffin-embedded endobronchial biopsy specimens from 27 children with difficult asthma (6–16 years) following treatment with systemic corticosteroids. Eleven non-asthmatic children (7–16 years) acted as controls. Reticular basement membrane (RBM) thickness was also recorded and forced expiratory volume in 1 second (FEV1) and exhaled nitric oxide (FENO) measured, the latter in asthmatic children only.Results: RBM thickness was greater in the asthmatic than the control group (median (range) 7.4 (3.1–11.1) v 5.1 (3.5–7.5) μm, p = 0.02). No other significant tissue difference was seen, nor was there a difference between asthmatic subjects with daily symptoms after systemic corticosteroids and those who became asymptomatic. CD4+ T lymphocyte density was higher in asthmatic subjects with persistent airflow limitation (post-bronchodilator FEV1
    Original languageEnglish
    Pages (from-to)862-869
    JournalThorax
    Volume59
    Issue number10
    DOIs
    Publication statusPublished - 2004

    Fingerprint Dive into the research topics of 'Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms'. Together they form a unique fingerprint.

    Cite this