This paper provides empirical evidence of agricultural adaptation strategies being adopted in the Mid-Hills regions of Nepal in response to climate change. Farmers were interviewed across four districts and climate change observations were reported, most notably those of increased temperatures and unpredictable precipitation. Agricultural adaptation strategies adopted in response to climate change were varied, with agroforestry and organic farming being the most popular practices. Most adaptation strategies were thought to be development-facing actions to reduce vulnerability, rather than specifically addressing climate change. From this research it is evident that indigenous knowledge, financial support and increased accessibility all play a pivotal role for successful climate change adaptation in the Mid-Hills. This case study provides valuable evidence-based research of autonomous adaptation techniques in a highly climate-vulnerable location of Nepal. Recommendations are made for donors to learn from best-practice and adopt local knowledge when investing in climate change adaptation strategies to most effectively reduce the vulnerability of some of the world's poorest communities. © 2013 Copyright Taylor and Francis Group, LLC.