Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain

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    Abstract

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized histopathologically by the abnormal deposition of the proteins amyloid-beta (Aβ) and tau. A major issue for AD research is the lack of an animal model that accurately replicates the human disease, thus making it difficult to investigate potential risk factors for AD such as head injury. Furthermore, as age remains the strongest risk factor for most of the AD cases, transgenic models in which mutant human genes are expressed throughout the life span of the animal provide only limited insight into age-related factors in disease development. Guinea pigs (Cavia porcellus) are of interest in AD research because they have a similar Aβ sequence to humans and thus may present a useful non-transgenic animal model of AD. Brains from guinea pigs aged 3–48 months were examined to determine the presence of age-associated AD-like pathology. In addition, fluid percussion-induced brain injury was performed to characterize mechanisms underlying the association between AD risk and head injury. No statistically significant changes were detected in the overall response to aging, although we did observe some region-specific changes. Diffuse deposits of Aβ were found in the hippocampal region of the oldest animals and alterations in amyloid precursor protein processing and tau immunoreactivity were observed with age. Brain injury resulted in a strong and sustained increase in amyloid precursor protein and tau immunoreactivity without Aβ deposition, over 7 days. Guinea pigs may therefore provide a useful model for investigating the influence of environmental and non-genetic risk factors on the pathogenesis of AD.

    Original languageEnglish
    Pages (from-to)1345-1351
    JournalNeurobiology of Aging
    Volume35
    Issue number6
    Early online date27 Nov 2013
    DOIs
    Publication statusPublished - Jun 2014

    Fingerprint

    Alzheimer Disease
    Guinea Pigs
    Pathology
    Wounds and Injuries
    Brain
    Amyloid beta-Protein Precursor
    Craniocerebral Trauma
    Brain Injuries
    Animal Models
    Percussion
    Serum Amyloid A Protein
    Age Factors
    Amyloid beta-Peptides
    Research
    Neurodegenerative Diseases
    Genes

    Cite this

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    title = "Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain",
    abstract = "Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized histopathologically by the abnormal deposition of the proteins amyloid-beta (Aβ) and tau. A major issue for AD research is the lack of an animal model that accurately replicates the human disease, thus making it difficult to investigate potential risk factors for AD such as head injury. Furthermore, as age remains the strongest risk factor for most of the AD cases, transgenic models in which mutant human genes are expressed throughout the life span of the animal provide only limited insight into age-related factors in disease development. Guinea pigs (Cavia porcellus) are of interest in AD research because they have a similar Aβ sequence to humans and thus may present a useful non-transgenic animal model of AD. Brains from guinea pigs aged 3–48 months were examined to determine the presence of age-associated AD-like pathology. In addition, fluid percussion-induced brain injury was performed to characterize mechanisms underlying the association between AD risk and head injury. No statistically significant changes were detected in the overall response to aging, although we did observe some region-specific changes. Diffuse deposits of Aβ were found in the hippocampal region of the oldest animals and alterations in amyloid precursor protein processing and tau immunoreactivity were observed with age. Brain injury resulted in a strong and sustained increase in amyloid precursor protein and tau immunoreactivity without Aβ deposition, over 7 days. Guinea pigs may therefore provide a useful model for investigating the influence of environmental and non-genetic risk factors on the pathogenesis of AD.",
    author = "Kristyn Bates and R. Vink and Ralph Martins and Alan Harvey",
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    Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. / Bates, Kristyn; Vink, R.; Martins, Ralph; Harvey, Alan.

    In: Neurobiology of Aging, Vol. 35, No. 6, 06.2014, p. 1345-1351.

    Research output: Contribution to journalArticle

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