Aging and cancer: The role of macrophages and neutrophils

Connie Jackaman, Federica Tomay, Lelinh Duong, Norbaini Bintu Abdol Razak, Fiona J. Pixley, Pat Metharom, Delia J. Nelson

    Research output: Contribution to journalReview article

    34 Citations (Scopus)

    Abstract

    Impaired immune function has been implicated in the declining health and higher incidence of cancer in the elderly. However, age-related changes to immunity are not completely understood. Neutrophils and macrophages represent the first line of defence yet their ability to phagocytose pathogens decrease with aging. Cytotoxic T lymphocytes are critical in eliminating tumors, but T cell function is also compromised with aging. T cell responses can be regulated by macrophages and may depend on the functional phenotype macrophages adopt in response to microenvironmental signals. This can range from pro-inflammatory, anti-tumorigenic M1 to anti-inflammatory, pro-tumorigenic M2 macrophages. Macrophages in healthy elderly adipose and hepatic tissue exhibit a more pro-inflammatory M1 phenotype compared to young hosts whilst immunosuppressive M2 macrophages increase in elderly lymphoid tissues, lung and muscle. These M2-like macrophages demonstrate altered responses to stimuli. Recent studies suggest that neutrophils also regulate T cell function and, like macrophages, neutrophil function is modulated with aging. It is possible that age-modified tissue-specific macrophages and neutrophils contribute to chronic low-grade inflammation that is associated with dysregulated macrophage-mediated immunosuppression, which together are responsible for development of multiple pathologies, including cancer. This review discusses recent advances in macrophage and neutrophil biology in healthy aging and cancer.

    Original languageEnglish
    Pages (from-to)105-116
    Number of pages12
    JournalAgeing Research Reviews
    Volume36
    DOIs
    Publication statusPublished - 1 Jul 2017

    Fingerprint

    Macrophages
    Neutrophils
    Aging of materials
    T-cells
    Neoplasms
    Tissue
    T-Lymphocytes
    Phenotype
    Cytotoxic T-Lymphocytes
    Lymphoid Tissue
    Pathology
    Pathogens
    Immunosuppressive Agents
    Phagocytosis
    Immunosuppression
    Muscle
    Adipose Tissue
    Tumors
    Immunity
    Anti-Inflammatory Agents

    Cite this

    Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017). Aging and cancer: The role of macrophages and neutrophils. Ageing Research Reviews, 36, 105-116. https://doi.org/10.1016/j.arr.2017.03.008
    Jackaman, Connie ; Tomay, Federica ; Duong, Lelinh ; Abdol Razak, Norbaini Bintu ; Pixley, Fiona J. ; Metharom, Pat ; Nelson, Delia J. / Aging and cancer : The role of macrophages and neutrophils. In: Ageing Research Reviews. 2017 ; Vol. 36. pp. 105-116.
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    Jackaman, C, Tomay, F, Duong, L, Abdol Razak, NB, Pixley, FJ, Metharom, P & Nelson, DJ 2017, 'Aging and cancer: The role of macrophages and neutrophils' Ageing Research Reviews, vol. 36, pp. 105-116. https://doi.org/10.1016/j.arr.2017.03.008

    Aging and cancer : The role of macrophages and neutrophils. / Jackaman, Connie; Tomay, Federica; Duong, Lelinh; Abdol Razak, Norbaini Bintu; Pixley, Fiona J.; Metharom, Pat; Nelson, Delia J.

    In: Ageing Research Reviews, Vol. 36, 01.07.2017, p. 105-116.

    Research output: Contribution to journalReview article

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    Jackaman C, Tomay F, Duong L, Abdol Razak NB, Pixley FJ, Metharom P et al. Aging and cancer: The role of macrophages and neutrophils. Ageing Research Reviews. 2017 Jul 1;36:105-116. https://doi.org/10.1016/j.arr.2017.03.008