Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease

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Abstract

Background
Dementia and affective and psychotic symptoms are commonly associated with Parkinson’s disease, but information about their prevalence and incidence in community representative samples remains sparse.

Methods
We recruited a community-representative sample 38173 older men aged 65–85 years in 1996 and used data linkage to ascertain the presence of PD, affective disorders, psychotic disorders and dementia. Diagnoses followed the International Classification of Disease coding system. Age was recorded in years. Follow up data were available until December 2011.

Results
The mean age of participants was 72.5 years and 333 men (0.9%) had PD at study entry. Affective and psychotic disorders and dementia were more frequent in men with than without PD (respective odds ratios: 6.3 [95%CI = 4.7, 8.4]; 14.2 [95%CI = 8.4, 24.0] and 18.2 [95%CI = 13.4, 24.6]). Incidence rate ratios of affective and psychotic disorders were higher among men with than without PD, although ratios decreased with increasing age. The age-adjusted hazard ratio (HR) of an affective episode associated with PD was 5.0 (95%CI = 4.2, 5.9). PD was associated with an age-adjusted HR of 8.6 (95%CI = 6.1, 12.0) for psychotic disorders and 6.1 (95%CI = 5.5, 6.8) for dementia. PD and dementia increased the HR of depressive and psychotic disorders.

Conclusions
PD increases the risk of affective and psychotic disorders, as well as dementia, among community dwelling older men. The risk of a recorded diagnosis of affective and psychotic disorders decreases with increasing age.
Original languageEnglish
Article number e0163781
Pages (from-to)1-13
JournalPLoS One
Volume11
Issue number9
DOIs
Publication statusPublished - 30 Sep 2016

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Psychotic Affective Disorders
dementia
Parkinson disease
Mood Disorders
Parkinson Disease
Dementia
Hazards
Psychotic Disorders
sampling
Independent Living
Affective Symptoms
Information Storage and Retrieval
Incidence
incidence
International Classification of Diseases
Depressive Disorder
odds ratio
Odds Ratio

Cite this

@article{eb08399b96bb4fa9bc7878ebf4eb5fee,
title = "Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease",
abstract = "BackgroundDementia and affective and psychotic symptoms are commonly associated with Parkinson’s disease, but information about their prevalence and incidence in community representative samples remains sparse.MethodsWe recruited a community-representative sample 38173 older men aged 65–85 years in 1996 and used data linkage to ascertain the presence of PD, affective disorders, psychotic disorders and dementia. Diagnoses followed the International Classification of Disease coding system. Age was recorded in years. Follow up data were available until December 2011.ResultsThe mean age of participants was 72.5 years and 333 men (0.9{\%}) had PD at study entry. Affective and psychotic disorders and dementia were more frequent in men with than without PD (respective odds ratios: 6.3 [95{\%}CI = 4.7, 8.4]; 14.2 [95{\%}CI = 8.4, 24.0] and 18.2 [95{\%}CI = 13.4, 24.6]). Incidence rate ratios of affective and psychotic disorders were higher among men with than without PD, although ratios decreased with increasing age. The age-adjusted hazard ratio (HR) of an affective episode associated with PD was 5.0 (95{\%}CI = 4.2, 5.9). PD was associated with an age-adjusted HR of 8.6 (95{\%}CI = 6.1, 12.0) for psychotic disorders and 6.1 (95{\%}CI = 5.5, 6.8) for dementia. PD and dementia increased the HR of depressive and psychotic disorders.ConclusionsPD increases the risk of affective and psychotic disorders, as well as dementia, among community dwelling older men. The risk of a recorded diagnosis of affective and psychotic disorders decreases with increasing age.",
author = "Almeida, {Osvaldo P.} and Kieran McCaul and Hankey, {Graeme J.} and Yeap, {Bu B.} and J. Golledge and Leon Flicker",
year = "2016",
month = "9",
day = "30",
doi = "10.1371/journal.pone.0163781",
language = "English",
volume = "11",
pages = "1--13",
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Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease. / Almeida, Osvaldo P.; McCaul, Kieran; Hankey, Graeme J.; Yeap, Bu B.; Golledge, J.; Flicker, Leon.

In: PLoS One, Vol. 11, No. 9, e0163781, 30.09.2016, p. 1-13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson's disease

AU - Almeida, Osvaldo P.

AU - McCaul, Kieran

AU - Hankey, Graeme J.

AU - Yeap, Bu B.

AU - Golledge, J.

AU - Flicker, Leon

PY - 2016/9/30

Y1 - 2016/9/30

N2 - BackgroundDementia and affective and psychotic symptoms are commonly associated with Parkinson’s disease, but information about their prevalence and incidence in community representative samples remains sparse.MethodsWe recruited a community-representative sample 38173 older men aged 65–85 years in 1996 and used data linkage to ascertain the presence of PD, affective disorders, psychotic disorders and dementia. Diagnoses followed the International Classification of Disease coding system. Age was recorded in years. Follow up data were available until December 2011.ResultsThe mean age of participants was 72.5 years and 333 men (0.9%) had PD at study entry. Affective and psychotic disorders and dementia were more frequent in men with than without PD (respective odds ratios: 6.3 [95%CI = 4.7, 8.4]; 14.2 [95%CI = 8.4, 24.0] and 18.2 [95%CI = 13.4, 24.6]). Incidence rate ratios of affective and psychotic disorders were higher among men with than without PD, although ratios decreased with increasing age. The age-adjusted hazard ratio (HR) of an affective episode associated with PD was 5.0 (95%CI = 4.2, 5.9). PD was associated with an age-adjusted HR of 8.6 (95%CI = 6.1, 12.0) for psychotic disorders and 6.1 (95%CI = 5.5, 6.8) for dementia. PD and dementia increased the HR of depressive and psychotic disorders.ConclusionsPD increases the risk of affective and psychotic disorders, as well as dementia, among community dwelling older men. The risk of a recorded diagnosis of affective and psychotic disorders decreases with increasing age.

AB - BackgroundDementia and affective and psychotic symptoms are commonly associated with Parkinson’s disease, but information about their prevalence and incidence in community representative samples remains sparse.MethodsWe recruited a community-representative sample 38173 older men aged 65–85 years in 1996 and used data linkage to ascertain the presence of PD, affective disorders, psychotic disorders and dementia. Diagnoses followed the International Classification of Disease coding system. Age was recorded in years. Follow up data were available until December 2011.ResultsThe mean age of participants was 72.5 years and 333 men (0.9%) had PD at study entry. Affective and psychotic disorders and dementia were more frequent in men with than without PD (respective odds ratios: 6.3 [95%CI = 4.7, 8.4]; 14.2 [95%CI = 8.4, 24.0] and 18.2 [95%CI = 13.4, 24.6]). Incidence rate ratios of affective and psychotic disorders were higher among men with than without PD, although ratios decreased with increasing age. The age-adjusted hazard ratio (HR) of an affective episode associated with PD was 5.0 (95%CI = 4.2, 5.9). PD was associated with an age-adjusted HR of 8.6 (95%CI = 6.1, 12.0) for psychotic disorders and 6.1 (95%CI = 5.5, 6.8) for dementia. PD and dementia increased the HR of depressive and psychotic disorders.ConclusionsPD increases the risk of affective and psychotic disorders, as well as dementia, among community dwelling older men. The risk of a recorded diagnosis of affective and psychotic disorders decreases with increasing age.

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DO - 10.1371/journal.pone.0163781

M3 - Article

VL - 11

SP - 1

EP - 13

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 9

M1 - e0163781

ER -