TY - JOUR
T1 - Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: A population-based cohort study
AU - Haggar, Fatima
AU - Pereira, Gavin
AU - Preen, David
AU - Holman, D'Arcy
AU - Einarsdóttir, Kristjana
PY - 2014
Y1 - 2014
N2 - © 2014 Haggar et al. Objective: To investigate obstetric and perinatal outcomes among female survivors of adolescent and young adult (AYA) cancers and their offspring. Methods: Using multivariate analysis of statewide linked data, outcomes of all first completed pregnancies (n=1894) in female survivors of AYA cancer diagnosed in Western Australia during the period 1982-2007 were compared with those among females with no cancer history. Comparison pregnancies were matched by maternal age-group, parity and year of delivery. Results: Compared with the non-cancer group, female survivors of AYA cancer had an increased risk of threatened abortion (adjusted relative risk 2.09, 95% confidence interval 1.51-2.74), gestational diabetes (2.65, 2.08-3.57), preeclampsia (1.32, 1.04-1.87), post-partum hemorrhage (2.83, 1.92-4.67), cesarean delivery (2.62, 2.22-3.04), and maternal postpartum hospitalization>5 days (3.01, 1.72-5.58), but no excess risk of threatened preterm delivery, antepartum hemorrhage, premature rupture of membranes, failure of labor to progress or retained placenta. Their offspring had an increased risk of premature birth (
AB - © 2014 Haggar et al. Objective: To investigate obstetric and perinatal outcomes among female survivors of adolescent and young adult (AYA) cancers and their offspring. Methods: Using multivariate analysis of statewide linked data, outcomes of all first completed pregnancies (n=1894) in female survivors of AYA cancer diagnosed in Western Australia during the period 1982-2007 were compared with those among females with no cancer history. Comparison pregnancies were matched by maternal age-group, parity and year of delivery. Results: Compared with the non-cancer group, female survivors of AYA cancer had an increased risk of threatened abortion (adjusted relative risk 2.09, 95% confidence interval 1.51-2.74), gestational diabetes (2.65, 2.08-3.57), preeclampsia (1.32, 1.04-1.87), post-partum hemorrhage (2.83, 1.92-4.67), cesarean delivery (2.62, 2.22-3.04), and maternal postpartum hospitalization>5 days (3.01, 1.72-5.58), but no excess risk of threatened preterm delivery, antepartum hemorrhage, premature rupture of membranes, failure of labor to progress or retained placenta. Their offspring had an increased risk of premature birth (
U2 - 10.1371/journal.pone.0113292
DO - 10.1371/journal.pone.0113292
M3 - Article
C2 - 25485774
VL - 9
SP - e113292
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
ER -
